Project Grant R37CA311069
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $133,598.00 under the Cancer Research Manpower program (CFDA 93.398) on June 23, 2025, with completion anticipated by May 31, 2027. This award supports research aimed at developing improved chemoprevention strategies for Familial Adenomatous Polyposis (FAP), a hereditary condition characterized by polyp formation and elevated cancer risk. The principal...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $119,172.00 under the Cancer Research Manpower program (CFDA 93.398) to support research addressing therapeutic response in non-small cell lung cancer (NSCLC). The project, initiated August 1, 2025, and completing July 31, 2027, focuses on developing computational approaches to integrate multi-modal and multi-omics biomedical datasets for improved...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $584,521 Project Grant on August 8, 2025, under the Cancer Treatment Research program (CFDA 93.395) to investigate subclonal determinants of radiation response in soft tissue sarcomas. The research will deliver three primary products: (1) identification and validation of epigenetic changes, including DNA methylation and chromatin accessibility alterations, that confer radioresistance to...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $368,294 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2028. This award supports the development of next-generation platforms for interrogating T cell receptor (TCR) specificity to identify and detect tumor antigens at the protein level. The project addresses a critical bottleneck in cancer...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant of $635,340 (awarded May 4, 2026, with completion targeted for April 30, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct functional genomic dissection of lung cancer in vivo. The research delivers comprehensive analysis of tumor suppressor gene function through an integrated approach combining genetically engineered mouse models,...
- Federal Grant Award Summary The National Cancer Institute awarded $411,206 to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) on May 14, 2026, with a project completion date of April 30, 2028. This Project Grant supports the development of small molecule inhibitors targeting the proton-sensing G protein-coupled receptor GPR68 as a novel therapeutic approach for pancreatic ductal adenocarcinoma (PDAC). The research addresses a critical clinical...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan $175,448 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with completion targeted for July 31, 2027. This project grant supports research training and investigator development in cancer biology, specifically focused on characterizing cancer-associated fibroblasts (CAFs) and their role in pancreatic ductal adenocarcinoma (PDAC). The research aims to...
- Summary of Cooperative Agreement Award The National Cancer Institute (NCI) awarded a $1.28 million Cooperative Agreement under the Cancer Biology Research program (CFDA 93.396) to The Leland Stanford Junior University on July 25, 2025, for research spanning through May 31, 2030. The research initiative, titled "Multiplexed Dissection of Metastatic Ability, Organ Tropism, and Immune Evasion," focuses on understanding how diverse pancreatic ductal adenocarcinoma (PDAC) cell states...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a Project Grant of $642,732 under the Cancer Cause and Prevention Research program (CFDA 93.393) beginning August 1, 2025, with a completion date of July 31, 2030. The award supports research to unravel heterogeneity in endometrial cancer through integrated single-cell genotype-phenotype mapping. The project addresses the critical need to refine molecular classification, improve...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded University of California, San Diego a $410,115 project grant under the Cancer Biology Research program (CFDA 93.396) beginning August 1, 2025, with completion scheduled for July 31, 2027. This research initiative develops improved preclinical models for pancreatic ductal adenocarcinoma (PDAC) by incorporating three-dimensional high-density type I collagen into tumor modeling systems. The project addresses a...
The National Cancer Institute (NCI) awarded a $357,370 Project Grant to The Leland Stanford Junior University effective May 5, 2026, through April 30, 2031, under the Cancer Treatment Research program (CFDA 93.395). The research focuses on reprogramming inflammatory cancer-associated fibroblasts (CAFs) to overcome therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC). The project will deliver fundamental research investigating myeloid differentiation factor 88 (MYD88) signaling as a therapeutic target, utilizing primary human cell models and mouse models of PDAC to determine whether inflammatory CAF differentiation can be suppressed through MYD88 inhibition. The award will generate research outcomes including elucidation of factors controlling the inflammatory CAF phenotype in PDAC, assessment of how CAF phenotypes influence the tumor microenvironment, and evaluation of the impact on tumor progression and treatment response. The research addresses a critical gap in cancer treatment, as current therapies targeting CAF development have paradoxically worsened tumor outcomes in PDAC patients. Deliverables will include peer-reviewed publications, experimental data, and preclinical findings that may inform future therapeutic development strategies for this exceptionally lethal malignancy.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $357.4k | 5/7/26 |