Project Grant R35NS136306

Award Date 12/1/24
Completion Date 11/30/32
Dollars Obligated $661K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the regulation of presynaptic gene transcripts during synaptogenesis in the nematode C. elegans. The $244,154 award, effective September 1, 2024 through June 30, 2027, will be executed by the Albert Einstein College of Medicine in Bronx, NY....
This federal Project Grant award of $551,250.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at the University of California, Los Angeles (UCLA) to uncover the molecular mechanisms regulating the formation of synaptic connections between neurons in the brain. The research aims to provide fundamental insights into the logic and mechanisms...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support research to elucidate how the ESCRT (Endosomal Sorting Complex Required for Transport) machinery is regulated and deployed in neurons. The $846,469 award to Brandeis University will fund the development of new visualization and manipulation tools to study ESCRT dynamics in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $235,887 to The Research Foundation For The State University Of New York, doing business as Stony Brook University, to develop a novel chemical strategy for light microscopy-based imaging of neural synapses and circuit connectivity in post-mortem specimens, including potentially...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $644,008 from February 21, 2025 to January 31, 2030 to The Research Foundation For The State University Of New York, doing business as Stony Brook University. The funding supports research on the role of non-vesicular lipid transport at endoplasmic reticulum-plasma...
This $412,500 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), supports research conducted by Louisiana State University Health Sciences Center New Orleans. The research aims to define the roles of the protein Coracle in regulating the dynamics of active zones - specialized structures in nerve terminals that control...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to develop a reversible fluorescent sensor technology called SynapShot for real-time monitoring of synaptic dynamics and connectivity in neural circuits. The $403,806 award to The Johns Hopkins University will enable researchers to investigate the functional...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $270,434 to The Trustees of Princeton University to investigate the role of spatiotemporal regulation of mRNA in neuronal remodeling during morphogenesis. The research will leverage Drosophila mushroom body and dendritic arborization neurons as models to...
This $274,218.64 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to Brandeis University will support research into the mechanisms underlying exosome release from neurons. The grant aims to determine how exosomes are generated from the endosomal system in neurons and explore neuronal exosome and endosome biology in an animal model. The grantee will manipulate the ESCRT and MUNC13-4/RAB11 pathways to investigate endosomal dynamics...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $404,340 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Georgia Research Foundation, Inc. The project aims to develop a novel method using split fluorescent protein tags to map the localization of neurotransmitter receptors within neural circuits in the Drosophila model organism. This work will provide crucial new insights into the...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $660,632 to the University of Wisconsin - Madison to conduct research on the structure and dynamics of fusion pores during neuronal synaptic vesicle release.

The key objectives of this multi-year research project (12/1/2024 - 11/30/2032) are to: 1) quantitatively measure the opening and closing rates, as well as size, of single fusion pores formed between synaptic vesicles and the presynaptic membrane; 2) determine the molecular structure of these fusion pores using cryo-electron microscopy; and 3) develop optical techniques to study the modes of synaptic vesicle release, specifically addressing whether they always undergo full fusion or can also undergo "kiss-and-run" exocytosis. This research aims to elucidate the fundamental nanomechanical processes underlying neuronal synaptic transmission, which is critical for understanding information flow in the nervous system.

Generated 6/24/25, 3:24 AM