This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will support the development of a novel chemical strategy to enable light microscopy-based imaging of neural synapses and circuit connectivity in post-mortem specimens, including potentially the human brain. The $235,887 award, spanning April 1, 2025 to March 31, 2027, will fund research to merge aspects of immunochemistry and lipophilic neural tracers to create a reactive neural tracer capable of synapse detection and circuit imaging in fixed tissue samples. The resulting capability to directly assess neural circuitry in post-mortem human specimens could have wide-ranging implications for understanding brain function and neurological disorders.
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