Project Grant R35GM166525
- The National Institute of General Medical Sciences awarded $414,394 to the University of California, Berkeley on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how endoplasmic reticulum structure and dynamics regulate cellular metabolic function and health. Work runs through May 31, 2031, at UC Berkeley's campus in Berkeley, California. The project uses metabolic flux approaches, enhanced focused ion beam scanning electron microscopy, and...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $1.624736 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds research into morphological reprogramming of the endoplasmic reticulum by cellular mucins. The project tests the hypothesis that transmembrane mucins act as membrane curvature generators on the luminal face of the endoplasmic...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The University of California, San Diego will collaborate on research integrating theory and experiment to unravel protein transport in the endoplasmic reticulum under a $551,789 project grant from the National Science Foundation. The grant was awarded January 15, 2021 under the Biological Sciences program (CFDA 47.074) to further the progress of the biological sciences and enhance understanding of major problems confronting the nation. Over a three-year period ending December 31, 2024, UC San...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences awarded $370,550 to the University of California, San Diego on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for development of the Intracellular Protein Organization Landscape (IPOL), a quantitative computational framework that characterizes cell types and states based on spatial protein organization rather than molecular composition. The award funds research integrating high-resolution imaging,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $686,308 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how microtubule- and actomyosin-based cytoskeletal networks are spatially regulated during cell division and development. The research integrates experiments in C. elegans embryos and cultured human cells, focusing on centrosomes and their role as microtubule-organizing centers. Work...
The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on August 24, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research mapping the structure and functions of the endoplasmic reticulum in health and disease. The project integrates single-molecule imaging, high-speed single protein tracking, and correlative cryo-fluorescence/electron microscopy to understand how endoplasmic reticulum ultrastructure affects its cellular functions. The work will quantitatively map protein distributions, dynamics, and ultrastructure across the entire endoplasmic reticulum network of living cells at nanoscale resolution, creating a spatially resolved framework for understanding how nanoscale architecture governs diverse endoplasmic reticulum functions including protein synthesis, folding and export, lipid metabolism regulation, calcium homeostasis, protein quality control, and the biogenesis of peroxisomes and lipid droplets. Performance occurs in La Jolla, California. The period of performance extends from August 24, 2026, through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 8/24/26 |