Project Grant R35GM166424
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on August 24, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research mapping the structure and functions of the endoplasmic reticulum in health and disease. The project integrates single-molecule imaging, high-speed single protein tracking, and correlative cryo-fluorescence/electron microscopy to understand how endoplasmic reticulum...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $387,596 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for engineering specialized organelles in yeast for compartmentalized production of therapeutics. The project re-engineers peroxisome and vacuole organelles in Saccharomyces cerevisiae as synthetic, specialized organelles for engineered...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $1.624736 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds research into morphological reprogramming of the endoplasmic reticulum by cellular mucins. The project tests the hypothesis that transmembrane mucins act as membrane curvature generators on the luminal face of the endoplasmic...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $441,375 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanobiology in tissue-mimetic contexts. The recipient's research addresses how cells sense, process, and respond to mechanical signals within their microenvironment, with focus on the viscoelastic properties of the...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $246,263 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into post-transcriptional regulatory networks and the integrated stress response (ISR). The work will comprehensively characterize the cofactors engaged by regulatory RNA-binding proteins and...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded $1,324,670 to the Regents of the University of California (operating Lawrence Berkeley National Laboratory) on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to enable time-resolved studies of small molecule-protein interactions with pharmacological relevance using serial crystallography. The research develops methods to follow structural changes in proteins in real time and under...
- The National Institute of General Medical Sciences awarded the University of California, Davis $432,417 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how linear and nonlinear mechanical forces in the extracellular matrix regulate cell metabolism through mechanotransduction pathways. The research uses induced pluripotent stem cells in both single-cell and organoid cultures within three-dimensional polymeric hydrogel systems to...
- The National Institute of General Medical Sciences awarded the University of California, Berkeley $329,491 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to elucidate the molecular basis of necroptosis through a five-year project extending to May 31, 2031. The funded research investigates the ZBP1-RIPK3-MLKL necroptosis pathway, specifically how ZBP1 transitions from inactive to assembled states to engage RIPK3, how MLKL undergoes conformational...
The National Institute of General Medical Sciences awarded $414,394 to the University of California, Berkeley on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how endoplasmic reticulum structure and dynamics regulate cellular metabolic function and health. Work runs through May 31, 2031, at UC Berkeley's campus in Berkeley, California. The project uses metabolic flux approaches, enhanced focused ion beam scanning electron microscopy, and super-resolution fluorescent microscopy to examine how structural regulation of the endoplasmic reticulum controls lipid and glucose fluxes in cells and how the organelle's architecture responds to nutrient sensing and signaling pathways. The research incorporates CRISPR-Cas9 screens coupled with high-content imaging and deep learning analysis to identify novel regulators of endoplasmic reticulum shape and function, introducing subcellular architectural remodeling as a regulatory layer in metabolic control.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $414.4k | 7/28/26 |