Project Grant R35GM166390
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $435,412 to the University of Houston System under the Biomedical Research and Research Training program (CFDA 93.859) for a two-year project commencing September 1, 2025. Principal Investigator Dr. Yu Liu will develop TO-Triplex-Seq, a novel whole-genome sequencing technology designed to identify and map RNA-DNA triple helix structures genome-wide. The technology leverages the differential affinity of...
- Federal Project Grant Award Summary William Marsh Rice University received a $521,194 Project Grant awarded July 1, 2026, from the National Science Foundation's Directorate for Engineering (CFDA 47.041, Engineering program). The award funds a three-year research initiative through June 30, 2029, focused on developing CRISPR Interference and Activation (CRISPRai) control systems to engineer mammalian cell factories for improved therapeutic protein manufacturing. The research addresses a...
- Federal Project Grant Summary Award Overview The National Institute of General Medical Sciences (NIGMS) awarded Rice University a $410,184 Project Grant effective April 1, 2026 through January 31, 2031 under the Biomedical Research and Research Training program (CFDA 93.859). This five-year research initiative, conducted at Rice University's Houston, Texas facility with a collaborative sub-award to Brigham Young University (awarded May 7, 2026), focuses on developing innovative synthetic...
- Federal Project Grant Award Summary William Marsh Rice University received a $986,944 Project Grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), awarded September 1, 2025, with completion targeted for August 31, 2028. The TOOLS4CELLS project develops self-replicating RNA (SrRNA) scaffolds derived from single-stranded RNA bacteriophages to enable safe, programmable, transient protein production across diverse bacterial species. The primary...
- Federal Grant Award Summary This $1,998,147 project grant, awarded by the National Science Foundation (NSF) Directorate for Engineering under the Engineering program (CFDA 47.041) on August 15, 2025, supports the development of an innovative biocomputing platform at Rice University. The research will create engineered bacterial consortia capable of performing parallel biological computing through integrated chemical and electronic signaling networks. The primary deliverable is the...
- Federal Grant Award Summary William Marsh Rice University received a $105,652 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded September 10, 2026, with a completion date of March 31, 2029. The project, "Enabling Extended Widefield Voltage Imaging with Low Phototoxicity," focuses on developing optimized genetically encoded voltage...
- Federal Project Grant Award Summary William Marsh Rice University received a $500,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective September 1, 2025, through August 31, 2028. The research project focuses on developing innovative methods to enhance the therapeutic protein secretion capacity of engineered cells for direct injection-based therapeutic...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of California, Los Angeles $433,125 through the Biomedical Research and Research Training program (CFDA 93.859) beginning April 1, 2026, with completion scheduled for February 28, 2031. This Project Grant supports the development and refinement of an imaging-based molecular recording technology designed to reconstruct the signaling history of individual cells. The research expands...
- Federal Project Grant Award Summary William Marsh Rice University received $828,803 in federal funding from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for a project titled "Deciphering the Dynamics of the Unfolded Protein Response." The award, effective August 15, 2025, with completion targeted for July 31, 2028, supports fundamental research aimed at understanding how cells determine their fate...
- Federal Project Grant Award Summary The University of Texas Health Science Center at San Antonio received a $433,125 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 1, 2026, with completion targeted for January 31, 2031. The award funds research investigating the spatiotemporal regulation of DNA metabolism pathways, specifically examining how homologous recombination (HR)...
William Marsh Rice University received a $405,251 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period August 1, 2026 through April 30, 2031. The award supports the development of a broad-spectrum DNA recorder—a synthetic biology tool enabling cells to create permanent DNA records of transient biological events, such as signaling pathway activation in living organisms. The research program specifically targets three development areas: engineering modular, inducible RNA polymerase III promoters responsive to diverse signaling pathways; establishing multi-site recording through naturally occurring genomic repeats rather than artificial sequence insertion; and improving prime editing efficiency by recruiting DNA repair factors to enhance insertion rates. The deliverables from this project will advance developmental biology research by enabling scientists to reconstruct the temporal history of gene expression in individual cells during development without requiring real-time observation. Success in optimizing the DNA recording platform—currently limited by coupling challenges, insufficient recording site capacity, and low editing efficiency (0.04-0.3 edits per day)—will provide unprecedented insights into embryonic development and organoid formation processes. The NIGMS support of this investigator-initiated basic research aligns with the Institute's mission to increase understanding of biological processes and lay the foundation for advances in disease diagnosis, treatment, and prevention.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $405.3k | 7/10/26 |