Project Grant R21GM160927
- This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...
- The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
- The University of Texas Health Science Center at Houston (UTHealth) was awarded a $868,584 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, which runs from September 1, 2025 to August 31, 2027, will fund research to investigate how RNA modifications regulate adaptive mRNA translation. The research aims to elucidate the roles of the TRMT1L RNA methyltransferase and its interaction with...
- The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger...
- This federal Project Grant award for $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of new tools for high-throughput characterization of extracellular RNA, DNA, and vesicles in bodily fluids. The primary objectives are to: 1) develop methods to reliably control for technical variability, RNA degradation, and complexity in cell-free RNA (cfRNA) analysis, including...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Electronic Biosciences, Inc. to develop the first technology capable of high-accuracy sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A) using nanopore sequencing. The project aims to merge innovative bisulfite adduct methodology with Electronic Biosciences' enzyme-free, multipass...
- This $383,482 Project Grant, awarded on June 6, 2025 by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research), aims to develop SPINSEQ, an innovative RNA sequencing platform capable of precise and accurate transcriptomic analysis. The project, conducted by Electronic Biosciences, Inc., a small biotechnology company in San Diego, California, focuses on maintaining RNA integrity and enabling improved detection of RNA modifications through advanced sequencing...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $275,989 Project Grant to William Marsh Rice University in Houston, TX. The grant, with a project period from March 1, 2025 to February 28, 2030, aims to develop advanced tools to visualize, quantify, and correlate DNA dynamics, organization, and gene activity in human cells with unprecedented resolution. The project will apply innovative labeling strategies, 3D nanoscale imaging, and...
- The Project Grant award, valued at $384,999 and provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports a research project conducted by The Leland Stanford Junior University (Stanford University). The project aims to address significant challenges in understanding RNA structure and its critical biological roles through a three-pronged approach: Developing computational tools, including an RNA sequence database (RNAMASS) and a novel...
- This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), will provide $215,088 to Directseq Biosciences, Inc. to develop an exhaustive de novo RNA sequencing method using next-generation mass spectrometry (NGMS-seq). The objective is to create a technology that can directly identify and sequence every RNA species in a sample, while also comprehensively profiling all RNA modifications, without bias....
The University of Houston System was awarded a $435,412 Project Grant from the National Institutes of Health (NIH) under the Biomedical Research and Research Training federal grant program (CFDA 93.859) to develop a new technology for whole-genome sequencing of RNA-DNA triplexes. The project aims to capture and characterize these novel RNA-DNA structures, which have important regulatory functions but are challenging to study using current methods. The core of the new technology, called TO-Triplex-Seq, involves using a fluorescent dye to label and purify RNA-DNA triplexes for genome-wide sequencing analysis. This innovation is expected to provide unprecedented insight into the roles of long non-coding RNAs in gene regulation, with potential implications for understanding developmental processes and disease mechanisms. The project will be led by Principal Investigator Dr. Yu Liu at the University of Houston and is scheduled for completion by August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.4k | 8/14/25 |