Project Grant 2444134
- This $515,885 project grant awarded by the National Science Foundation's (NSF) Engineering program (CFDA 47.041) to The Trustees of Columbia University in the City of New York aims to improve the production and quality of T cells for use in immunotherapies. The project focuses on understanding how the stiffness and chemical composition of biomaterials used to culture T cells impact their growth, function, and phenotype. Specifically, the researchers will investigate how controlling nutrient...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $828,803 aims to better understand how cells determine their fate when under stress in the endoplasmic reticulum (ER), the cell's power plant that produces and folds proteins. The research project at William Marsh Rice University develops new tools to investigate how genes behave in real-time and create systems to help cells better manage protein production under stress. The...
- William Marsh Rice University was awarded a $425,741 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems on February 15, 2021 to develop novel mammalian cell-based devices that sense and respond. The award has a completion date of January 31, 2024. The funding is provided through the NSF Directorate for Engineering's Engineering program (CFDA 47.041), which seeks to improve quality of life and economic strength through...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $275,989 Project Grant to William Marsh Rice University in Houston, TX. The grant, with a project period from March 1, 2025 to February 28, 2030, aims to develop advanced tools to visualize, quantify, and correlate DNA dynamics, organization, and gene activity in human cells with unprecedented resolution. The project will apply innovative labeling strategies, 3D nanoscale imaging, and...
- The National Science Foundation (NSF) awarded a $623,295 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to William Marsh Rice University in Houston, TX. The purpose of this 3-year grant, with an award date of August 1, 2025, is to develop new methods for isolating, studying, and utilizing a wider variety of DNA plasmids as tools to program microbes for beneficial purposes. The research aims to expand the current limited plasmid toolbox from a few to potentially...
- The National Science Foundation (NSF) awarded a $297,984 Project Grant under the Engineering program (CFDA 47.041) to the University of Texas Health Science Center at Houston (UTHealth). The grant supports collaborative research to quantify the mechanical forces inside living cells and determine how changes in these forces impact the production and secretion of proteins that shape the cellular environment. The goal is to develop predictive tools using mechanical forces to control cell...
- This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $574,808 to Duke University over 5 years to study the origins of cellular heterogeneity in T-cell therapies. The research leverages cutting-edge technologies like spatial proteomic multiplexed imaging, in vitro cell tracking, and engineered biomaterial artificial antigen-presenting cells to better understand how single-cell variability arises during the growth and modification of...
- This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...
- This $500,000 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences Program (CFDA 47.049), supports research to develop a mathematical framework for understanding how porous materials can enhance the efficiency of viral transduction in engineered cell therapies. The award was granted to North Carolina State University (UEI: U3NVH931QJJ3) and will run from September 1, 2025 to August 31, 2028. The key objective of this project is to...
- This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $240,146 to the University of Alabama to conduct collaborative research on the effects of cellular deformation on the proliferation and motility of single cells. The research aims to engineer specialized microfluidic devices that simulate the tight spaces cells encounter in the human body, enabling the observation of how physical stress impacts cell division, movement, and...
This $500,000 Project Grant was awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) to William Marsh Rice University in Houston, Texas. The funding will support research to increase the secretion capacity of therapeutic cells, enabling them to produce higher levels of proteins to aid in disease treatment. The project aims to understand the mechanisms driving high antibody production in plasma cells and apply these insights to modify existing therapy-grade cells. Key activities include manipulating the expression of transcription factors and other regulatory elements, developing methods to systematically tune these factors, and establishing controlled processes to trigger cell reprogramming. The goal is to maximize the functional secretion properties of engineered cells, addressing challenges with growth arrest and post-mitotic phenotypes. This research will advance the practical deployment of cell-based therapeutic strategies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 8/15/25 |