Project Grant R35GM166367
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $433,780 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative chemical reactions for drug discovery. The funded research pursues two research directions. First, the recipient will develop stereoselective catalytic reactions to synthesize chiral N-heterocycles—sp3-rich scaffolds prevalent in FDA-approved drugs—using...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $566,384 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to engineer modular polyketide synthases (PKS) for medicinal chemistry and drug discovery. The research synthesizes over 100 new macrolide antibiotics by refactoring and module-swapping a pikromycin synthase platform in the chassis organism Escherichia coli K207-3, establishing proof-of-principle that...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Arlington $339,676 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop light-responsive osmium compounds as metallo-reagents for biomedical imaging and photoactivation. The project develops osmium-based...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded Texas Tech University Health Sciences Center $492,625 under CFDA 93.859 (Biomedical Research and Research Training) on September 1, 2026, to support research on quality control pathways governing protein translocation and folding in the endoplasmic reticulum. The research focuses on understanding molecular mechanisms regulating protein movement...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $386,811 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic platforms for studying multivalent molecular recognition and communication. The funded research, led by the Callmann Lab, will create programmable polymeric scaffolds that isolate and systematically test individual variables—density, stereochemistry, topology, and...
- The National Institute of General Medical Sciences awarded Texas A&M Engineering Experiment Station $394,917 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced label-free microscopy methods linking cell structure to mechanobiology. The work focuses on quantitative phase imaging and holotomography as nondestructive, non-contact tools for visualizing cytoskeletal structure and predicting cell viscoelasticity in live, unlabeled cells....
- The National Institute of General Medical Sciences awarded Texas A&M University System Health Science Center $418,952 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop light-controlled tools and genetically encoded sensors for studying calcium signaling at membrane contact sites in living cells. The research program integrates three directions. First, the team will engineer light-activated actuators to control organelle positioning and...
- The National Institute of Biomedical Imaging and Bioengineering, a component of the Department of Health and Human Services National Institutes of Health, awarded $184,063 to the University of Texas at San Antonio on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of forced-dimerization activated photoacoustic aptamer switch sensors (FDA-PASS), optical probes designed to enable...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $456,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to explore RNA polymerase dynamics and regulatory architecture across divergent bacterial species. The recipient will develop and apply a new sequencing platform that enables purified RNA polymerase to transcribe entire bacterial genomes under defined biochemical conditions, with...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Texas Southwestern Medical Center $449,900 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new methods for detecting protein phosphorylation in cells. The project will exploit a novel bacterial effector protein, Legionella pneumophila LnaB, which attaches adenosine monophosphate...
The National Institute of General Medical Sciences awarded Texas Tech University $383,858 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to develop predictive design principles linking fluorescent polymer architecture to pharmacokinetics for near-infrared (NIR-II) bioimaging applications. The project, titled "Design Maps Linking Polymer Architecture and Pharmacokinetics: A Platform for Generalizable Bioimaging," establishes universal design rules that couple fluorescent polymer structure with biological fate by systematically varying polymer topology, molecular weight, and composition to generate quantitative design maps predicting optical performance (brightness, quantum yield, emission stability) and biological outcomes (clearance route, circulation half-life, organ retention, immune evasion). These principles will be validated across diverse polymer scaffolds and applied to biomedical contexts including renal diagnostics and vascular imaging. The work addresses a critical gap in NIR-II probe translation: current development remains empirical, producing agents that are either bright but poorly characterized or biocompatible but dim. By transforming nanoprobe development into a predictive science, the research will advance real-time molecular imaging capabilities for surgical navigation, intraoperative guidance, and noninvasive functional diagnostics. Performance occurs in Texas. The award period runs through March 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $383.9k | 7/24/26 |