Project Grant R01EB039757
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Arlington $378,411 on April 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop super-resolution tomographic imaging technology for deep tissue visualization. The project aims to overcome diffraction limits inherent in existing super-resolution imaging modalities—including super-resolution fluorescence...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Texas at Dallas $486,805 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop margination-mediated delivery and glutathione-triggered release mechanisms enabled by renal-clearable gold nanoparticles for fluorescence-guided surgery of brain metastases. The project addresses a clinical gap: current...
- The National Institute of Biomedical Imaging and Bioengineering, a component of the Department of Health and Human Services National Institutes of Health, awarded $184,063 to the University of Texas at San Antonio on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of forced-dimerization activated photoacoustic aptamer switch sensors (FDA-PASS), optical probes designed to enable...
- The National Institute of General Medical Sciences awarded Texas Tech University $383,858 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to develop predictive design principles linking fluorescent polymer architecture to pharmacokinetics for near-infrared (NIR-II) bioimaging applications. The project, titled "Design Maps Linking Polymer Architecture and Pharmacokinetics: A Platform for Generalizable Bioimaging," establishes universal design...
- The National Cancer Institute awarded the University of Texas at Arlington $565,569 under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on June 1, 2026, for the design and synthesis of light-responsive osmium compounds to enable optical image-guided surgery and phototherapy in cancer treatment. The project will develop osmium compounds that luminesce at near-infrared wavelengths where tissue is most transparent, with the compounds engineered to be nontoxic to healthy tissue...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $232,550 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a mid-infrared photothermal fiber probe for label-free imaging and biomolecular composition analysis in endoscopic applications. The project will develop a fiber-based probe that integrates mid-infrared photothermal imaging with...
- The National Institute of Biomedical Imaging and Bioengineering awarded Texas Christian University $495,541 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop metal-doped graphene quantum dots as dual-mode contrast agents combining ultrasound and near-infrared fluorescence imaging. The research will synthesize and optimize biocompatible metal-doped graphene quantum dots to overcome limitations of...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded 37Degrees, Inc. $360,247 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type: Project Grant). The award funds development of photoacoustic microscopy systems for non-destructive, three-dimensional imaging of live and incubated engineered tissue. The project addresses a critical gap in...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Research Foundation of The City University of New York $151,168 on September 5, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop machine learning-enhanced molecular modeling of near-infrared fluorescent materials for bioimaging applications. The project addresses limitations in current near-infrared fluorescent probes used for surgical...
- The National Institute of General Medical Sciences awarded $430,109 to The Regents of the University of California, operating Lawrence Berkeley National Laboratory, on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop deeply subwavelength near infrared imaging technology using avalanching nanoparticles. The project addresses fundamental limitations of live-cell optical microscopy by creating avalanching nanoparticles (ANPs) that upconvert incident...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Arlington $339,676 on August 18, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop light-responsive osmium compounds as metallo-reagents for biomedical imaging and photoactivation. The project develops osmium-based molecular tools designed to convert, store, and emit light with high precision, emitting in the near-infrared II window (900–1700 nanometers) where tissue is most transparent to enable clearer and deeper imaging compared to conventional optical probes. The research integrates quantum modeling, chemical synthesis, nanoscale confinement benchmarking, and biological testing in a feedback loop to establish design principles linking molecular structure to photochemical function. The deliverables include establishing design rules for bright near-infrared II emissive osmium compounds, determining how nanoscale confinement modulates emission and photoreactivity, and demonstrating their application as optical tools for imaging and photoactivation in biological models. The platform unites visualization with targeted light-triggered reactivity—termed image-guided photodynamic modulation—in a single molecular system. The award runs through July 31, 2030, with place of performance in Arlington, Texas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $339.7k | 8/17/26 |