Project Grant R35GM166033
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $566,384 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to engineer modular polyketide synthases (PKS) for medicinal chemistry and drug discovery. The research synthesizes over 100 new macrolide antibiotics by refactoring and module-swapping a pikromycin synthase platform in the chassis organism Escherichia coli K207-3, establishing proof-of-principle that...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $771,265 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural and functional imaging of macromolecular machines involved in gene regulation using cryo-electron microscopy. The research encompasses three principal investigative avenues: mechanisms of RNA-guided CRISPR-Cas surveillance, methods to determine structures of human protein...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $270,208 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on molecular mechanisms and developmental control of PAR polarity in animal embryos. The research resolves the network of protein-protein interactions that supports animal cell polarity and explores how this network responds to developmental signals. The work centers on an...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $491,703 in Project Grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the molecular mechanisms of cohesin-mediated three-dimensional genome organization. The recipient will conduct mechanistic studies of how the cohesin complex, the architectural protein CTCF, its unloading factor WAPL, and regulatory RNAs collaborate to...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $433,780 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative chemical reactions for drug discovery. The funded research pursues two research directions. First, the recipient will develop stereoselective catalytic reactions to synthesize chiral N-heterocycles—sp3-rich scaffolds prevalent in FDA-approved drugs—using...
- The National Institute of General Medical Sciences awarded the University of Texas Health Science Center at Houston $423,576 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning-driven computational tools for interpreting electron cryo-microscopy and electron cryo-tomography data of complex biological assemblies. The project addresses significant gaps in current cryo-EM modeling software by building a unified framework to model...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $429,650 on April 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the interplay between cellular metabolism, chromatin regulation, and transcriptional control in ethylene signaling and stress responses in Arabidopsis. The research explores how chromatin-modifying enzymes utilize metabolic cofactors to influence histone modifications, nucleosome structure,...
- The National Institute of General Medical Sciences awarded the University of Texas at Austin $415,574 on July 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on immune recognition and response mechanisms in choanoflagellates. The project establishes choanoflagellates—the closest living relatives of animals—as experimental models for investigating host-pathogen interactions and innate immune response. Research will combine comparative...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Texas Southwestern Medical Center $449,900 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new methods for detecting protein phosphorylation in cells. The project will exploit a novel bacterial effector protein, Legionella pneumophila LnaB, which attaches adenosine monophosphate...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
The National Institute of General Medical Sciences awarded the University of Texas at Austin $386,811 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic platforms for studying multivalent molecular recognition and communication. The funded research, led by the Callmann Lab, will create programmable polymeric scaffolds that isolate and systematically test individual variables—density, stereochemistry, topology, and stimulus-responsiveness—that control multivalent interactions in biological systems. Program 1 will prepare a panel of polymers with defined architectural variations to establish reproducible benchmarks showing how macromolecular structure shapes protein recognition and extracellular matrix-like assembly. Program 2 will design polymers incorporating redox and ionic triggers to measure how dynamic temporal control alters binding, clustering, and assembly outcomes. The research will operate across molecular, supramolecular, and cellular scales to extract general design rules underlying multivalent recognition and function in living systems. Performance runs through April 30, 2031, at the University of Texas at Austin in Austin, Texas. The University of Texas System serves as the parent entity to the University of Texas at Austin.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $386.8k | 8/14/26 |