Project Grant R35GM166361
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $420,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and deploy genetic interaction mapping tools in bacteria. The project will construct a comprehensive genetic interaction network in Escherichia coli by developing a barcoded CRISPR strategy to systematically profile all pairwise genetic interactions (approximately 10 million) and...
- The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $336,000 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate apical junction fluidity control during epithelial morphogenesis. The research examines the role of Prickle 2 (PK2), a core component of the planar cell polarity pathway, in controlling the flexibility and directionality of junctional remodeling. The work focuses on...
- The National Institute of General Medical Sciences awarded $462,000 to Icahn School of Medicine at Mount Sinai on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to support research into the molecular mechanisms of gating and selectivity in the MSCs and MRS2 superfamilies of ion channels. The research combines biochemical, biophysical, and electrophysiological approaches to understand two ion channel superfamilies: mechanosensitive...
- The National Institute of Neurological Disorders and Stroke awarded Icahn School of Medicine at Mount Sinai $1,967,309 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the role of small non-coding RNAs in microglia-driven neuroinflammation in Alzheimer's disease. The funded research will elucidate how small non-coding RNAs—including microRNA isoforms, transfer RNA-derived fragments, ribosomal RNA-derived...
- The National Institute of Mental Health awarded Icahn School of Medicine at Mount Sinai $462,000 on August 14, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop a novel spatial transcriptomics platform and investigate RNA-binding protein function in human neurons as it relates to schizophrenia risk. The award funds two primary aims. The first develops a spatial RNA-protein interactome MERFISH (SPRIM) platform to visualize endogenous RNA-protein interactions at...
- The National Institutes of Health National Human Genome Research Institute awarded Icahn School of Medicine at Mount Sinai $2,583,834 on April 13, 2026, under the Human Genome Research program (CFDA 93.172) to develop computational methods for analyzing spatial omics data and characterizing tissue microenvironment organization. The recipient will develop a modeling framework called ONTRAC that uses tissue niches as the basic structural component for analyzing spatial transcriptomic and...
- The National Institute of Allergy and Infectious Diseases awarded Icahn School of Medicine at Mount Sinai $156,510 on March 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on how hepatocytes and skeletal myocytes shape immunity to mRNA-lipid nanoparticle-encoded protein. The research addresses off-target mRNA uptake and expression in hepatocytes and skeletal myocytes during mRNA-LNP delivery. The investigator will engineer...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Icahn School of Medicine at Mount Sinai $742,478 on July 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to elucidate how RNA-lipid nanoparticle transfection and expression in professional antigen-presenting cells and non-professional antigen-presenting cells—specifically hepatocytes and skeletal myocytes—modulate T cell responses to RNA-encoded protein. The...
- The National Institute of General Medical Sciences awarded $464,750 to the Mount Desert Island Biological Laboratory on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to explore tissue-specific mechanisms and requirements for nucleolin organization in living C. elegans. The research investigates how the RNA binding protein nucleolin organizes within the nucleolus and its role in ribosome biogenesis and disease. The project uses C. elegans and the...
- Federal Grant Award Summary Icahn School of Medicine at Mount Sinai received a $462,454 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 8, 2025 through June 30, 2027. The award supports research investigating DNA methylation (5-methylcytosine) dynamics in Down syndrome (trisomy 21) hematopoiesis and leukemia development. The primary deliverable involves mapping epigenetic...
The National Institute of General Medical Sciences awarded Icahn School of Medicine at Mount Sinai $462,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance spatial imaging frameworks that reveal how non-coding RNAs organize within the nucleus across developmental and environmental contexts. The research establishes three interconnected themes. Theme 1 extends RNA MERFISH to profile small non-coding RNAs by incorporating enzymatic amplification strategies such as in situ polyadenylation and T7 amplification, enabling spatial mapping of both short and long non-coding RNAs. Theme 2 defines the spatial positioning of non-coding RNAs within nuclear bodies and tracks how these associations are remodeled during neuronal differentiation, integrating RNA MERFISH with multiplexed nuclear body protein imaging and expansion microscopy. Theme 3 dissects structural protein and non-coding RNA localization in Cajal and histone locus bodies and probes necessity and sufficiency through knockdown followed by modular protein domain rescues. The award supports work performed at Icahn School of Medicine at Mount Sinai in New York, New York, with a period of performance from August 1, 2026, through May 31, 2031. The assistance type is a Project Grant. NIGMS supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $462.0k | 7/24/26 |