Project Grant R01HG014190
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $462,981.00 under the Biomedical Research and Research Training program (CFDA 93.859) on August 15, 2025, with a completion date of July 31, 2030. This research initiative addresses sepsis, a leading cause of hospital mortality worldwide, by leveraging modern biobanks to advance understanding of sepsis biology and clinical outcomes. The...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded Fred Hutchinson Cancer Center a $2.41 million Project Grant on September 19, 2025, for the development of an experimental-data-based in silico data generation platform to enhance single-cell and spatial omics data analysis. Under CFDA 93.172 (Human Genome Research), the project will deliver three primary products through August 31, 2029: (1) statistical methods and tools for generating in silico...
- Federal Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded Columbia University's Health Sciences Division a Project Grant of $3.24M under the Human Genome Research program (CFDA 93.172) for research on computational and experimental approaches to decode domain-specific protein-RNA interactions. The four-year project, initiated April 1, 2026 and concluding March 31, 2030, addresses a critical gap in understanding how RNA-binding proteins (RBPs) regulate gene...
- Cooperative Agreement Award Summary The National Human Genome Research Institute (NHGRI) awarded Icahn School of Medicine at Mount Sinai a Cooperative Agreement valued at $1,547,918 under the Human Genome Research program (CFDA 93.172) for the period of April 1, 2026 through March 31, 2028. This MAGEN Development Site will develop state-of-the-art artificial intelligence (AI) and genomics models to advance personalized cancer risk assessment, monitoring, and prevention. The primary...
- The National Human Genome Research Institute (NHGRI) awarded a $993,446 Project Grant under the Human Genome Research Federal Grant Program (CFDA 93.172) to the Sloan-Kettering Institute for Cancer Research. The 5-year grant, commencing on May 1, 2025, aims to develop statistical and machine learning approaches that connect human genetics data with single-cell omics data to improve the understanding of the genetic architecture underlying complex diseases. Key goals include decoding the...
- Federal Project Grant Award Summary Boston Medical Center Corporation has been awarded $3,371,645 by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) to develop scalable software engineering methods and computational tools for large-scale subcellular spatial omics analysis. The four-year project, initiated September 1, 2025, and concluding August 31, 2029, addresses critical barriers in spatial subcellular transcriptomics research by...
- Federal Project Grant Award Summary Boston Children's Hospital received a $130,680 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective July 1, 2025 through June 30, 2027. The award supports the development of computational technologies and statistical methods for single-cell functional genomics analysis. The research deliverables include: (1) deep learning computational frameworks to decode epigenetic...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded a Project Grant of $266,664 to Massachusetts Institute of Technology (MIT) on August 18, 2025, with a project completion date of July 31, 2027. This five-year research initiative focuses on developing a functional genomics measurement platform called MIT-SEQ to quantify translation initiation kinetics across the human genome. The research...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI) awarded University of California Santa Cruz $633,116 on September 26, 2025, under the Human Genome Research program (CFDA 93.172) to advance comparative genomics through three integrated research objectives. The project, which extends through June 30, 2029, will deliver scalable computational tools and methodologies for analyzing thousands of vertebrate genomes. Primary deliverables include: (1) an automated...
- Federal Project Grant Award Summary The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded Dana-Farber Cancer Institute, Inc. a Project Grant of $501,618 beginning September 1, 2025, and concluding June 30, 2029. This award supports the development of computational tools for variant calling from long genomic and RNA-sequencing (RNA-seq) reads, addressing critical gaps in current genomic analysis methodologies. The project will deliver...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), awarded $2.58M to Icahn School of Medicine at Mount Sinai for a project titled "Niche Trajectory Analysis of Spatial Omics Data" (April 13, 2026 – March 31, 2030). The award funds the development of computational tools and methodologies to advance understanding of tissue microenvironment organization through spatial transcriptomic and epigenomic analysis. Specifically, the project deliverables include: (1) creation of a novel modeling framework called ONTRAC (Niche Trajectory Analysis of Spatial Omics Data) for constructing niche trajectories from spatial transcriptomic and epigenomic data; (2) extension of the ONTRAC framework to analyze subcellular RNA localization patterns; and (3) comprehensive characterization of tissue microenvironment organization in acute kidney injury mice using systems biology approaches. The research will generate sophisticated computational tools and analytical methods that enable biologists and clinicians to investigate the structural organization and function of tissue microenvironments in both healthy and diseased states. By using the "niche"—defined as cell-cell interactions and their tissue microenvironment context—as the fundamental structural unit rather than individual cells, this project advances the field's capacity to understand how tissue organization changes during physiological processes such as development and aging, as well as during disease onset and progression.Summary of Federal Project Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 4/17/26 |