Project Grant R35GM165595
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $393,689 in project grant funding on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research defining mechanisms that couple nutrient sensing to functional programs in non-malignant mammalian cells. The...
- The National Cancer Institute, an office of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $657,443 on September 1, 2026, under the Cancer Biology Research program (CFDA 93.396, Assistance Listing R01CA315392). The award funds structural and mechanistic studies of the RAS/RAF MAPKINASE pathway to achieve atomic-resolution understanding of how these proteins recognize and interact with one another and how these interactions...
- The National Institutes of Health Office of the Director awarded Dana-Farber Cancer Institute, Inc. $845,500 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to design de novo allosteric proteins that sense and respond to small molecules. The research aims to develop "active" proteins that undergo conformational changes upon ligand binding, enabling programmable control of signaling at the nanoscale. The work combines computational design and...
- The National Institute of General Medical Sciences awarded $502,372 to Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop selective, catalytic isomerization reactions that convert simple organic building blocks into complex organic molecules relevant to biomedical research. The work encompasses stereocenter editing—precise interconversion of stereoisomeric molecules at late synthetic stages to enable...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $528,000 to Sloan-Kettering Institute for Cancer Research on April 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate histone glycation as a dynamic epigenetic mark. The award funds research into non-enzymatic covalent modifications (NECMs) of histones, specifically glycation through methylglyoxal, a...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $121,866 on August 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop open-source computational workflows for metabolite structural elucidation in untargeted metabolomics. The project will expand the ICEBERG geometric deep learning model to train on curated open-source datasets (GNPS, MassSpecGym) through knowledge distillation from proprietary models and...
- The National Institute of General Medical Sciences awarded the University of Connecticut Health Center $423,352 on March 18, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate dead cell-phagocyte interaction at the phagosomal interface. The award funds research using a proximity-labeling technique called PhagoP1 to profile protein compositions of dead-cell-containing phagosomes and decode death-associated cellular responses. The research applies this...
- The National Cancer Institute, a division of the National Institutes of Health under the Department of Health and Human Services, awarded $134,000 to the University of Massachusetts Medical School on September 3, 2026, under the Cancer Biology Research program (CFDA 93.396). The recipient will conduct research employing genetically engineered mouse models to elucidate mechanisms by which loss of CAMK2B (calcium/calmodulin-dependent protein kinase II beta) promotes metastasis and immune...
- The National Institute of General Medical Sciences awarded The Wistar Institute of Anatomy and Biology $506,550 under the Biomedical Research and Research Training program (CFDA 93.859) on April 1, 2026, to investigate mechanisms controlling the development of TIM4+ macrophages. The award funds a five-year research program (April 1, 2026 through March 31, 2031) conducted in Philadelphia, Pennsylvania. The research addresses how TIM4- macrophages develop into TIM4+ macrophages following their...
- The National Cancer Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $134,919 under the Cancer Research Manpower program (CFDA 93.398) on June 11, 2026. The award funds structure-function and mechanistic studies of the protein-O-mannosyl transferase (POMT) complex in pediatric low-grade gliomas driven by the KIAA1549:BRAF fusion. The research aims to determine high-resolution structures of the POMT...
The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded $416,815 to Dana-Farber Cancer Institute, Inc. on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support mechanistic research on metabolite signaling in tissue resident macrophages. The funded research aims to identify how metabolites regulate macrophage function across diverse tissue environments and how perturbations in metabolite signaling drive inflammatory disease. The work includes metabolomics profiling of interstitial fluid and tissue resident macrophages across eight tissues to define extracellular metabolic milieus and intracellular metabolite signatures in vivo, followed by systematic mechanistic interrogation of metabolite signaling pathways. The research addresses a critical knowledge gap regarding both the metabolite environment surrounding tissue resident macrophages in living organisms and the molecular mechanisms through which metabolites control macrophage homeostatic and inflammatory functions. Dana-Farber Cancer Institute, a nonprofit academic medical research organization affiliated with Harvard Medical School headquartered in Boston, Massachusetts, serves as the recipient. The award covers the period from August 3, 2026, through March 31, 2031, with place of performance in Boston, MA. This is a Project Grant, the standard assistance type for investigator-initiated biomedical research within NIGMS's portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.8k | 8/3/26 |