Project Grant K99CA312664
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $721,653 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective June 5, 2026, with a completion date of May 31, 2031. The research focuses on identifying protein O-mannosylation as a therapeutic vulnerability in KIAA1549-BRAF-driven pediatric low-grade gliomas (PLGGs), the most common solid tumors in childhood. The project deliverables include fundamental...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $341,280 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective July 1, 2025 through June 30, 2027. This award supports a K99/R00 Pathway to Independence research project investigating the role of histone cleavage in triple-negative breast cancer (TNBC), with emphasis on understanding the KDM4C histone demethylase protein and its tumorigenic mechanisms....
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $1.71 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective September 1, 2025, through July 31, 2032. The award supports research into new approaches for targeting cell cycle proteins in cancer treatment, specifically focusing on cyclin-dependent kinase (CDK) inhibitor development and therapeutic applications. The research addresses critical...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $170,641 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) for the period August 1, 2025 through July 31, 2027. The award supports research training and investigator development focused on advancing understanding of tumor-immune interactions in colorectal cancer through multimodal spatial profiling analysis. The project will utilize highly multiplexed...
- Federal Project Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $235,491 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective May 1, 2026, through April 30, 2031. This award funds research training and career development activities focused on advancing biomedical knowledge in cancer research aligned with the National Cancer Program's strategic priorities. The grant supports institutional capacity building to...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $110,190 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded on December 27, 2025, with a completion date of June 30, 2028. The award supports research training and career development in cancer immunotherapy, specifically focused on unraveling the mechanisms of neoantigen vaccine-induced epitope spreading (ES). The project will systematically investigate how...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Dana-Farber Cancer Institute, Inc. a Project Grant of $275,990 under the Cancer Research Manpower program (CFDA 93.398) effective September 2, 2025, with completion targeted for August 31, 2026. This award supports the development of engineered living materials (ELMs) as programmable therapeutic implants for pancreatic ductal adenocarcinoma (PDAC), a devastating cancer with a five-year survival rate below 5%. The primary...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Dana-Farber Cancer Institute, Inc. a Project Grant totaling $645,102 under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on cell cycle control mechanisms. The five-year award, which commenced on July 1, 2026 and concludes on June 30, 2031, supports investigation into the molecular mechanisms governing WEE1 kinase—specifically how this regulatory protein transitions between functioning as...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration within the School of Medicine a Project Grant totaling $109,076.00 under the Cancer Research Manpower program (CFDA 93.398) on December 17, 2025. The award supports biomedical research training and career development initiatives focused on cancer research through September 1, 2029. This project grant funds the institution's capacity to provide integrated...
- Federal Grant Award Summary Dana-Farber Cancer Institute received a $151,040 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded on December 23, 2025, with a completion date of September 14, 2027. This award supports postdoctoral research training and investigation into the structural mechanisms of oligomeric BAK (BAKO), a pro-apoptotic protein in the BCL-2 family. The research aims to elucidate how full-length BAK self-associates and...
Dana-Farber Cancer Institute, Inc. received a $134,919 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective June 11, 2026, with completion targeted for May 31, 2028. This award supports biomedical research training and career development focused on cancer research aligned with the National Cancer Program's strategic priorities. The institute will leverage this funding to provide research training infrastructure and support investigator development in oncology across multiple research disciplines. The specific research initiative funded under this award focuses on structure-function and mechanistic studies of the protein-O-mannosyl transferase (POMT) complex in fusion-driven pediatric low-grade gliomas. The project will characterize the POMT complex through high-resolution structural analysis using cryo-electron microscopy (cryo-EM) techniques, mutagenesis studies, and functional assays to elucidate the complex's mechanisms in KIAA1549:BRAF-driven tumors. This research addresses an urgent clinical need, as pediatric low-grade gliomas represent the most common childhood central nervous system tumor and current therapeutic approaches face significant limitations including resistance and toxicity. The identification of POMT complex dependency as a tumor vulnerability offers potential for developing novel therapeutic approaches tailored to fusion-driven pediatric gliomas.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $134.9k | 6/12/26 |