Project Grant DP2GM170825
- The National Institutes of Health Office of the Director awarded the Trustees of Boston University $1,144,500 on September 4, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop nanobody-based probes that enable precise, multiplexed, and genetically-encoded perturbations to protein conformations and states in human cells. The work will generate a novel class of probes to realize large-scale, unbiased protein interaction mapping through pooled screening methodologies,...
- The National Cancer Institute, an office of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $657,443 on September 1, 2026, under the Cancer Biology Research program (CFDA 93.396, Assistance Listing R01CA315392). The award funds structural and mechanistic studies of the RAS/RAF MAPKINASE pathway to achieve atomic-resolution understanding of how these proteins recognize and interact with one another and how these interactions...
- The National Institute of General Medical Sciences awarded $150,104 to The Regents of the University of California, San Francisco on August 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to design de novo allosterically regulated proteins for studying intramolecular signal transduction. The recipient will design helical bundle proteins capable of ligand-triggered small-molecule release, with two specific applications: designing a protein that releases the...
- The National Institutes of Health Office of the Director awarded The Broad Institute, Inc. $831,250 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to develop novel nanoprobes and advanced imaging techniques that extend single-molecule fluorescence microscopy capabilities in living cells. The project addresses fundamental limitations in visualizing G-protein-coupled receptor (GPCR) signal transduction. Current single-molecule imaging methods photobleach within...
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded $416,815 to Dana-Farber Cancer Institute, Inc. on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support mechanistic research on metabolite signaling in tissue resident macrophages. The funded research aims to identify how metabolites regulate macrophage function across diverse tissue environments...
- The National Cancer Institute, within the Department of Health and Human Services, awarded Dana-Farber Cancer Institute, Inc. $718,275 on July 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to investigate context-specific pathway dependencies for nuclear envelope proteins in brain cancer. The research addresses how nuclear envelope-associated proteins perform distinct biochemical functions across different cellular contexts in central nervous system cancers. The project uses an...
- The National Institute of General Medical Sciences awarded Boston Interactome, Inc. $349,753 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop the Integrated Two-Hybrid (I2H) platform for protein-protein interaction mapping and drug discovery. Boston Interactome will develop I2H as a next-generation PPI detection platform combining multiple protein expression backgrounds and detection modes to achieve 80–90% coverage of protein-protein...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Brigham & Women's Hospital Inc. $230,388 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop small molecule inhibitors of the E3 ligase NEDD4. The project consists of two research aims. Aim 1 investigates the structural dynamics of the NEDD4 HECT domain through NMR spectroscopy, using different...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $267,000 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research decoding gasdermin D (GSDMD) pore clustering as a regulatory checkpoint controlling pyroptosis, a lytic and inflammatory form...
- The National Institutes of Health Office of the Director awarded Dana-Farber Cancer Institute $893,657 on June 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to upgrade the NMR console on an 800 MHz spectrometer. The award funds replacement of a 19-year-old Avance NEO 800 MHz NMR console at the institute's Boston facility. The new console will enable the Arthanari Lab to deploy advanced NMR methods including in situ/closed-loop optimization of NMR pulse sequences and...
The National Institutes of Health Office of the Director awarded Dana-Farber Cancer Institute, Inc. $845,500 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to design de novo allosteric proteins that sense and respond to small molecules. The research aims to develop "active" proteins that undergo conformational changes upon ligand binding, enabling programmable control of signaling at the nanoscale. The work combines computational design and experimental validation to establish design principles for small-molecule-induced allosteric communication. The recipient will build designed ligand-binding helical bundles connected through frustrated linkers and bioinspired approaches mimicking G-protein coupled receptor signaling mechanisms, then test these designs for cooperative binding and characterize the sequence-structure relationships governing allostery. The ultimate goal is to establish fully synthetic, fit-for-purpose GPCR-like systems with novel programmable and small-molecule-inducible functions. Performance takes place in Boston, Massachusetts. The period of performance runs from September 1, 2026, through August 31, 2031. The award is assistance type Project Grant and is subject to NIH audit and record retention requirements under OMB 2 CFR 200 and 45 CFR 75.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $845.5k | 8/25/26 |