Project Grant R35GM165547
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Arizona State University $713,338 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2025, for a five-year research project examining mammal-microbial coevolution mechanisms and health implications. The award supports investigator-initiated basic research designed to advance understanding of how host organisms and their microbiomes coevolve and how disruptions...
- Federal Project Grant Award Summary Arizona State University received a $700,000 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), effective August 1, 2025, through July 31, 2028. The award funds research to elucidate and understand "covert" or non-obligate metabolic interactions within synthetic microbial communities—interactions that are not essential to community survival but...
- Federal Project Grant Award Summary Arizona State University received a $1,977,264 Project Grant award, effective September 15, 2025, through August 31, 2029, under the National Institute of General Medical Sciences' Biomedical Research and Research Training program (CFDA 93.859). The award funds development of a novel multimodal imaging platform that integrates fluorescence super-resolution and tomographic polarized light imaging technologies to enable cellular and unicellular organism...
- Federal Grant Award Summary Arizona State University received a $847,599 Project Grant award from the National Science Foundation's Division of Molecular and Cellular Biosciences (CFDA 47.074) effective September 1, 2025, through August 31, 2028, to conduct collaborative research on the structural and functional mechanisms of bacterial gliding motility. The project will investigate how soil bacteria utilize specialized molecular machinery—specifically rotating motors that drive a protein-based...
- Federal Project Grant Award Summary Arizona State University received a $413,036 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2027. The award supports the development of a novel single-molecule glycosaminoglycan (GAG) sequencing method using fluorophore-labeled lysosomal enzymes. Glycosaminoglycans are large, linear, sulfated...
- Federal Grant Award Summary The University of Arizona received a $410,775 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Prof. Riedel-Kruse, the project advances synthetic biology tools and approaches focused on engineering bacterial multicellular consortia. Deliverables include the development of...
- Federal Grant Award Summary Arizona State University received a $418,016 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the evolutionary origins of intracellular parasitism. The award, effective July 18, 2025 through June 30, 2027, funds two primary research objectives: (1) establishing a molecular map of subcellular structures in Chromera velia, a free-living...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Health Research, Inc. Wadsworth Center a $386,003 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective August 1, 2026, through June 30, 2031. This award supports fundamental research investigating mechanisms of bacterial defense against conjugative plasmids and their phages, with specific focus on understanding how bacteria resist plasmid acquisition...
- Federal Grant Award Summary The University of Arizona received a $376,481 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through March 31, 2031. This research initiative focuses on developing bioinspired design principles for therapeutic microcarriers that resist immune system clearance and respond to biological stress. The project addresses a critical...
- Federal Project Grant Award Summary The University of Arizona received a $2.09 million Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 5, 2025, through September 4, 2029. This early-stage investigator-led research project will investigate the molecular mechanisms underlying commensal microbiota responses to host physiological stress. The research team will conduct...
Arizona State University's Office of Research and Sponsored Projects Administration received a $404,180 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 13, 2026, with completion targeted for March 31, 2031. The award funds the D'Souza Lab's investigation into Type VI Secretion System (T6SS) mediated predation in microbial communities. The research examines how bacterial antagonism shapes ecological and evolutionary dynamics, specifically focusing on T6SS-enabled predatory behavior whereby bacteria lyse susceptible neighboring cells to access released nutrients in nutrient-poor environments. The study employs two model systems: a marine bacterial pair (T6SS Vibrio anguillarum with Vibrio cyclitrophicus prey) and a synthetic pair (T6SS Vibrio cholerae with Escherichia coli prey). Over the five-year funding period, the research deliverables include defining operating principles for predation in nutrient-poor and spatially structured environments using microfluidic microcosms, automated time-lapse microscopy, quantitative image analytics, targeted genetics, experimental evolution, and comparative genomics. The work aims to characterize how predatory bacteria locate prey growth hotspots, select effectors, and optimize T6SS deployment for nutritional gain. Additional research objectives encompass testing whether bacterial species can share T6SS components to complement antagonistic functions in multi-genotypic communities, thereby connecting gene, cellular, and community-level dynamics to advance understanding of natural microbiome function.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.2k | 7/10/26 |