Project Grant 2530162
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal Project Grant award provides $501,879.00 to the University of Chicago to conduct collaborative research on the structural and functional mechanisms of a molecular conveyor belt machinery that drives bacterial gliding motility. The project aims to determine how multiple rotary motors on the bacterial surface coordinate to propel a protein-based conveyor belt, enabling cell movement analogous to a molecular...
- This $265,007 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support collaborative research to advance the understanding of bacterial swimming motion. The research aims to leverage robophysical modeling techniques from robotics to realistically emulate and study the complex interplay of physical and biological factors governing bacterial motility behaviors. Key objectives include elucidating how fluid mechanical forces shape the ways...
- This National Science Foundation project grant of $512,676 will fund research at Duke University from August 2022 to July 2025 under the Biological Sciences program (CFDA 47.074). The research aims to advance understanding of mechanosensitive channels in bacteria through single-molecule force spectroscopy experiments using an atomic force microscope. Investigators will observe the opening of individual mechanosensitive channels in living E. coli and B. subtilis bacteria in response to mechanical...
- This Project Grant award of $876,272.00 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) will fund collaborative research to develop advanced genetic manipulation tools for bacteria. The project aims to expand the biotechnological capabilities of marine bacteria called Vibrios, which are important in food production, disease, and host-microbe interactions. The research will focus on scaling up methods to influence the expression of individual bacterial genes...
- The National Science Foundation (NSF) awarded a $626,831 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Wisconsin-Milwaukee (UWM) to conduct collaborative research on the molecular mechanisms behind how certain bacteria use light-sensing proteins called phytochromes to regulate essential developmental processes. The project aims to use advanced structural biology techniques like cryo-electron microscopy and time-resolved X-ray crystallography to study...
- This $700,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program supports a research project at Arizona State University (ASU) to "Elucidate, Understand, and Leverage 'Covert' Metabolic Interactions in Synthetic Microbial Communities". The project aims to reveal valuable, previously unknown microbial interactions that could be leveraged to engineer microbial communities for applications in food production, high-value...
- This $380,500 National Science Foundation project grant supports collaborative research at the University of California, Los Angeles to analyze mechanosensitive channels in bacteria using force spectroscopy. The research team will utilize atomic force microscopy to observe the opening of single mechanosensitive channels in living bacteria in response to mechanical compression. This will help characterize how these channels function to protect bacteria from rupturing due to excessive internal...
- The University of Arizona received a $587,130 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering federal grant program (CFDA 47.041). The award will support research from June 2023 to May 2026 exploring the biomechanics and chemotaxis of the pathogenic bacterium Leptospira interrogans. The research will examine how specific bacterial proteins influence physical structure and movement, interaction with...
- This National Science Foundation (NSF) Project Grant award under CFDA Program 47.041 - Engineering, in the amount of $232,786, will support collaborative research on robophysical modeling of bacterial swimming motion. The project aims to advance the understanding of how fluid mechanical forces shape the ways bacteria navigate their complex environments and interact with each other. By adopting techniques of robophysical modeling, the researchers will isolate physical effects governing...
- This $325,937 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research at Michigan State University (MSU) to interrogate the interconnection of structural and metabolic dynamics of evolutionarily distinct bacterial microcompartments. The project aims to study the impact of geometry and permeability of microcompartments in two distantly related bacteria under varying realistic environments, with the goal of gaining...
This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $847,599 to Arizona State University to conduct collaborative research on the structural and functional mechanisms of a molecular conveyor belt machinery that drives bacterial gliding motility. The research integrates expertise in genetics, biophysics, and cryo-electron tomography to explore how multiple rotating motors on the bacterial surface coordinate to drive a protein-based conveyor belt, enabling cell movement analogous to a molecular snowmobile. The key objectives are to determine how the rotary motors cooperate to propel the conveyor belt, elucidate the distribution of tension across the belt, and identify the polymerization mechanism and molecular basis for directional control. The project also aims to develop interactive online educational tools to enhance public understanding and student engagement in microbiology. The award period runs from Sep 1, 2025 to Aug 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $847.6k | 8/18/25 |