Project Grant R35GM165397
- The National Institute of General Medical Sciences awarded the University of Rochester $448,196 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic tools for constructing carbon-nitrogen bonds using N-aryl and N-alkenyl nitrogen intermediates. The research targets the synthesis of nitrogen heterocycles, which are critical structural components in pharmaceuticals and natural products. The project will develop catalytic methods to...
- The National Institute of General Medical Sciences awarded $502,372 to Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop selective, catalytic isomerization reactions that convert simple organic building blocks into complex organic molecules relevant to biomedical research. The work encompasses stereocenter editing—precise interconversion of stereoisomeric molecules at late synthetic stages to enable...
- The National Institute of General Medical Sciences awarded $548,084 to the University of North Texas Research and Innovation Division on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop ruthenium(II)-catalyzed enantioselective functionalization of arene and alkene derivatives for asymmetric synthesis of natural products and complex organic molecules. The research targets enantioselective functionalization of ortho- and meta-aryl C-H bonds...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $226,560 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new catalytic methods for modular synthesis of saturated, nitrogen-containing heterocycles guided by mechanism-aware machine learning models. The research addresses a bottleneck in active pharmaceutical ingredient (API)...
- The National Institute of General Medical Sciences, a component of the National Institutes of Health, awarded The University of Chicago $590,711 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports development of new synthetic methods to accelerate preparation of diverse analogues for medicinal chemistry studies. Over the five-year performance period ending June 30, 2031, the research addresses carbon-carbon...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $150,104 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate stereoselective hydrogen atom abstraction using chiral amine-borane catalysts and develop a deracemization protocol for converting racemic starting materials into high-value enantioenriched products, specifically targeting beta2- and gamma2-amino acids. The research will leverage the...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded New York University $185,462 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning schemes that predict rare biomolecular events using short molecular dynamics trajectories rather than computationally prohibitive long simulations. The research addresses the challenge of characterizing infrequent biological phenomena—such as insulin dimer dissociation, which can require...
- The National Institute of General Medical Sciences awarded The Research Foundation For The State University of New York $434,892 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and biosynthetic research on natural product enzymes. The award funds investigation of nonribosomal peptide synthetases (NRPSs) and NRPS-independent siderophore biosynthetic pathways, with focus on the conformational dynamics that NRPSs employ to...
The National Institute of General Medical Sciences awarded New York University $392,356 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop cascade synthesis methods for heterocyclic scaffolds using S-alkyl metal complexes. The project leverages unexplored reactivity of S-alkyl transition-metal intermediates to create cascade reactions that merge C-H activation, functional group migration, and heterocycle construction. The first research direction focuses on copper-catalyzed annulative alkene translocation cascades utilizing S-alkyl copper intermediates to achieve radical-based olefin migrations, applying one-electron C-H activation to generate oxygen- and nitrogen-containing spirocycles through coupling of aziridines and epoxides with bifunctional nucleophiles. A second project explores heterocycle construction through ligand-controlled S-alkyl palladium cascades, where ligand choice directs C-H activation to either proximal gamma-methylene or distal delta-methyl sites. These methods establish a platform to generate bioactive scaffolds with versatile olefin handles for downstream derivatization. Performance occurs in New York, New York. The award runs through April 30, 2031. This is a Project Grant, the assistance type NIGMS uses for investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $392.4k | 8/20/26 |