Project Grant R01GM169399
- The National Institute of General Medical Sciences awarded Albert Einstein College of Medicine $361,200 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for predicting and simulating interactions between cell surface proteins with multiple domains in the immunoglobulin fold. The project addresses a fundamental challenge in structural biology: current experimental methods cannot reliably measure transient interactions...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded New York University $421,737 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop data-driven, predictive biophysical models of molecular mechanisms underlying cellular quiescence in microorganisms. The research focuses on quantitative relations between physiological traits and molecular processes in...
- The National Institute of General Medical Sciences awarded New York University $466,125 in a Project Grant (R35GM166362) on July 15, 2026, to develop artificial intelligence methods for predicting the molecular mechanisms by which genetic mutations cause disease. The work integrates large-scale experimental datasets with protein language models to train AI systems that predict rich molecular mutation effects beyond binary damaging-or-neutral classifications, including effects on protein...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $269,071 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply cryo-electron microscopy and cryo-electron tomography methods for visualizing protein machine assembly, function, and regulation at high resolution. The work emphasizes development of the CryoDRGN and TomoDRGN software ecosystem to enable structural analysis of complex samples in...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and...
- The National Institute of General Medical Sciences awarded the University of New Mexico $370,940 on August 22, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop high-throughput free energy computational methods for small molecule, peptide, and protein design in drug discovery and optimization. The project integrates enhanced sampling methods with multisite lambda dynamics (MSLD) to create MSLD++, a framework intended to overcome computational...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $125,000 on May 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated computational and experimental platform for decoding, modulating, and designing protein free energy landscapes. The funded research will establish methods for resolving complete protein free energy landscapes and predicting how they respond to...
- The National Institute of General Medical Sciences awarded Cornell University $760,645 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop algorithms for quantitative recovery of biomolecular structural ensembles from cryo-EM data. The funded research addresses protein conformational change by developing methods to quantitatively recover the probabilities of protein conformational states from cryogenic-sample electron microscopy...
- The National Institute of General Medical Sciences awarded Duke University $375,996 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop protein language model innovations for sequence design and functional prediction. The award funds three representation-learning advances addressing limitations in current protein language models. Aim 1 creates length-invariant generative representations that systematically explore insertions, deletions, and...
- The National Institute of General Medical Sciences awarded New York University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a K99/R00 project investigating mitonuclear regulation in Caenorhabditis elegans. The research aims to determine how interactions between mitochondrial and nuclear genomes regulate gene expression and stress responses across tissues. Using natural mitochondrial variation in C. elegans combined with...
The National Institute of General Medical Sciences awarded New York University $185,462 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning schemes that predict rare biomolecular events using short molecular dynamics trajectories rather than computationally prohibitive long simulations. The research addresses the challenge of characterizing infrequent biological phenomena—such as insulin dimer dissociation, which can require hours or days of simulation time despite femtosecond-scale integration demands—by approximating transition rates and key dynamical statistics from datasets of brief trajectories seeded throughout the state space. The work will generate approximation functions for transition rates, committors, and mean first-passage times, and will include strategies to adapt simulation models to match experimentally obtained estimates. Work is performed in New York, New York. The award runs through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $185.5k | 8/7/26 |