Project Grant R35GM163543
- The National Institute of General Medical Sciences (NIGMS) awarded the University of California Irvine $503,280 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the enzymatic mechanism and heterologous expression of nitrogenase. Over a five-year performance period ending January 31, 2031, the recipient will use genetic, biochemical, spectroscopic, and structural approaches to probe nitrogenase's reaction mechanism, focusing on stepwise...
- The National Institute of General Medical Sciences awarded the University of California Irvine $487,953 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate nitrogenase assembly and reactivity over five years. The research combines genetic, biochemical, spectroscopic, and structural approaches to understand how the M-cluster metallocofactor of molybdenum nitrogenase is assembled into a functional unit. Specific investigations include the...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $150,104 under the Biomedical Research and Research Training program (CFDA 93.859) on March 1, 2026. The award funds de novo design of artificial haloperoxidase enzymes using machine-learning tools for protein design and structure prediction. The research investigates metalloenzyme structure-function relationships through design of vanadium- and heme-dependent haloperoxidase enzymes that oxidize...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded $124,767 to The Regents of the University of California, San Francisco on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance de novo protein design for catalysis and fluorescence imaging. The research tests the hypothesis that protein dynamics, particularly enrichment of productive conformations, contribute to enhanced catalytic rates in engineered proteins. Prior work under this funding...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $420,981 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop engineered enzymatic catalysts for asymmetric hydrogen atom transfer reactions in synthetic chemistry. The research integrates organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve biocatalysts that enable...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and...
The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of catalytically reducing N2 into NH3. The research program addresses key mechanistic gaps: how ATP hydrolysis is utilized for N2 reduction, and what constitutes the intimate mechanism of N2 reduction on the nitrogenase active site cluster (FeMoCo). The investigator initiated a research program to structurally characterize dynamic states of nitrogenase at atomic resolution under enzymatic turnover conditions using cryo-EM complemented by biophysical and biochemical analyses. Place of performance is La Jolla, California. The period of performance runs from September 1, 2026, through August 31, 2031. This is a Project Grant, a standard assistance type under the NIGMS portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $507.3k | 7/29/26 |