Project Grant R35GM161248
- The National Institute of General Medical Sciences, a component of the National Institutes of Health, awarded The University of Chicago $590,711 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports development of new synthetic methods to accelerate preparation of diverse analogues for medicinal chemistry studies. Over the five-year performance period ending June 30, 2031, the research addresses carbon-carbon...
- The National Institute of General Medical Sciences awarded New York University $392,356 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop cascade synthesis methods for heterocyclic scaffolds using S-alkyl metal complexes. The project leverages unexplored reactivity of S-alkyl transition-metal intermediates to create cascade reactions that merge C-H activation, functional group migration, and heterocycle construction. The first research...
- The National Institute of General Medical Sciences awarded the University of Rochester $578,733 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the biological roles of tRNA modification enzymes. The award funds research combining biochemistry, molecular biology, and genetics to resolve knowledge gaps about how tRNA modifications impact tRNA structure and function, the roles of vertebrate-specific tRNA modification enzymes, and how these...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Science Foundation awarded the University of Rochester $550,692 in project grant funding on February 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new synthetic reactions using N-alkenylnitrones and N,O-dialkenylhydroxylamines as reactive intermediates. The research team is developing unconventional strategies to rapidly assemble novel molecules with defined three-dimensional structure by controlling the rearrangement reactivity of these...
- The National Institute of General Medical Sciences awarded The University of Chicago $124,929 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop improved aminating reagents and photocatalytic amide bond coupling methods for biomedical synthesis. The award funds mechanistic analysis of o-sulfonylhydroxyl amine-derived aminating reagents to establish the mechanism of n-amination of heterocyclic compounds, design safer and more effective...
- The National Institute of General Medical Sciences awarded $338,892 to the University of Illinois on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for organometallic chemistry research on nickel enzymes. The project focuses on developing catalytic and functional mimics of acetyl-coenzyme A synthase (ACS) and [NiFe] hydrogenase through the design of flexible multidentate ligands with mixed hard/soft donor atoms. The research aims to detect and...
- The National Institute of General Medical Sciences awarded the University of Rochester $427,227 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of gene-regulatory RNA molecules called riboswitches. The funded research uses high-resolution structural approaches and in-cell methods to elucidate how riboswitches sense metabolites and ions through conformational changes that control downstream gene expression. The...
- The National Institute of General Medical Sciences awarded $548,084 to the University of North Texas Research and Innovation Division on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop ruthenium(II)-catalyzed enantioselective functionalization of arene and alkene derivatives for asymmetric synthesis of natural products and complex organic molecules. The research targets enantioselective functionalization of ortho- and meta-aryl C-H bonds...
- The National Institute of General Medical Sciences awarded $1,184,200 to the University of Montana on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop high-valent dinuclear cobalt-oxo complexes for studying enzymatic bond activation and formation processes. The project runs through March 31, 2030, with work performed in Missoula, Montana. The research uses biomimetic and bio-inspired first-row transition metal complexes to understand how natural...
The National Institute of General Medical Sciences awarded the University of Rochester $448,196 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic tools for constructing carbon-nitrogen bonds using N-aryl and N-alkenyl nitrogen intermediates. The research targets the synthesis of nitrogen heterocycles, which are critical structural components in pharmaceuticals and natural products. The project will develop catalytic methods to generate and control the reactivity of nitrosoalkenes, nitroarene radical anions, and N-aryl nitrenoids from precursors including nitroalkenes, nitroarenes, aryl amines, and aryl azides. Work will focus on mild base metal-catalyzed deoxygenation reactions and electrochemical single-electron reduction strategies to enable novel carbon-nitrogen bond formation in biomedical scaffolds that are currently difficult to access with existing synthetic methods. Performance will occur in Chicago, Illinois, with a period of performance through August 31, 2031. The assistance type is a Project Grant, supporting basic research that advances understanding of biological processes and provides foundation for disease diagnosis, treatment, and prevention advances.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.2k | 8/21/26 |