Project Grant R35GM162598
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $393,689 in project grant funding on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research defining mechanisms that couple nutrient sensing to functional programs in non-malignant mammalian cells. The...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $635,367 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms of cell division and cell signaling. The research addresses how micron-scale microtubule structures organize as signaling scaffolds in cell division and Hedgehog signal transduction. In the cell-division strand, the work focuses on...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $444,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop secreted genetically encoded fluorescent biosensors for in vivo extracellular imaging. The project will create a toolkit of biosensors across four research areas: imaging extracellular matrix structures by conjugating fluorescent proteins to lectins and...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $453,750 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, through Project Grant R35GM165865. The award funds research investigating how mitochondrial metabolism regulates species-specific developmental rates in mammalian embryos. The research program uses an in vitro system that recapitulates the two- to threefold difference in...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $443,090 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds a five-year research program investigating the mechanisms of perioperative neurocognitive disorder, a neurotoxic condition arising from anesthesia and surgery that is characterized by declines in memory, attention, and executive...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Boston $425,333 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular and molecular mechanisms of stem and progenitor cell development during tissue homeostasis and after injury. The research uses the Drosophila melanogaster blood system as a model to examine how multiple cell types within stem and progenitor cell niches use inflammatory...
- The National Institute of General Medical Sciences awarded President and Fellows of Harvard College $508,111 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis and selectivity of membrane proteins mediating transport, signaling, and metabolic pathway regulation. The research combines experimental techniques including X-ray crystallography and single-particle cryogenic electron microscopy with functional assays in vitro and...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $433,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop network-based computational models for understanding continuous cell states in human development and disease. Over five years through February 28, 2031, the research group will create methods to integrate multiple modalities of large-scale genomics data, with emphasis on epigenetics and the...
- The National Cancer Institute awarded The General Hospital Corporation (Massachusetts General Hospital) $659,201 on June 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct research on the integrated stress response in glioblastoma pathogenesis and response to therapy. The funded research investigates how glioma stem cells survive and proliferate within the hostile glioblastoma microenvironment through adaptive stress response mechanisms. The work focuses on the...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $437,036 on June 1, 2026, for genomic enzymology research to decipher bacterial membrane-associated glycan assembly under the Biomedical Research and Research Training program (CFDA 93.859). The funded work identifies and assigns functional signatures for substrate specificity in phosphoglycosy transferase and glycosyltransferase enzymes to enable glycan composition inference at the protein sequence...
The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $453,750 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate novel molecular mechanisms of nutrient signaling networks in plants, specifically exploring how Target-of-Rapamycin (TOR) signaling promotes growth and development while repressing stress-innate immunity, and to characterize calcium-sensor protein kinases (CPKs) and their roles in nitrate signaling. The research uses Arabidopsis thaliana as a model organism to address fundamental gaps in understanding glucose and nitrate signaling mechanisms that integrate gene expression, metabolism, growth, and stress-immune responses across multicellular organisms. Work is performed in Boston, Massachusetts, with a period of performance from September 1, 2026, through April 30, 2031. This Project Grant is classified as an investigator-initiated award under NIGMS's basic research portfolio, supporting the Institute's mission to increase understanding of biological processes that lay the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $453.8k | 8/13/26 |