Project Grant R35GM161352
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded $298,662 to Massachusetts General Hospital on June 15, 2026, to conduct collaborative research into long-range signaling and computation in microtubules under the Biological Sciences program (CFDA 47.074). The research tests the hypothesis that individual microtubule polymers function as transmitters and amplifiers of conformational signals within cells, departing from the conventional view of microtubules...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $393,689 in project grant funding on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research defining mechanisms that couple nutrient sensing to functional programs in non-malignant mammalian cells. The...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $453,750 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, through Project Grant R35GM165865. The award funds research investigating how mitochondrial metabolism regulates species-specific developmental rates in mammalian embryos. The research program uses an in vitro system that recapitulates the two- to threefold difference in...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $443,090 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds a five-year research program investigating the mechanisms of perioperative neurocognitive disorder, a neurotoxic condition arising from anesthesia and surgery that is characterized by declines in memory, attention, and executive...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $444,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop secreted genetically encoded fluorescent biosensors for in vivo extracellular imaging. The project will create a toolkit of biosensors across four research areas: imaging extracellular matrix structures by conjugating fluorescent proteins to lectins and...
- The National Institute of General Medical Sciences awarded The Marine Biological Laboratory $471,625 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate Wnt pathway activation and cell signaling using sea star oocytes as a model system. The research examines how Dishevelled (DVL), a protein essential to Wnt pathway integration, assembles into cytoplasmic structures upon hormonal stimulation of oocytes, and investigates oocyte-derived...
- The National Institute of General Medical Sciences awarded President and Fellows of Harvard College $1.6 million on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to examine the physical mechanisms by which FtsZ filaments deform bacterial membranes to initiate cell division. The project investigates how FtsZ and FtsA filament condensation overcomes membrane tension to initiate the initial invagination step of bacterial cytokinesis, a process that...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Boston $425,333 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular and molecular mechanisms of stem and progenitor cell development during tissue homeostasis and after injury. The research uses the Drosophila melanogaster blood system as a model to examine how multiple cell types within stem and progenitor cell niches use inflammatory...
- The National Institute of Child Health and Human Development awarded The General Hospital Corporation (Massachusetts General Hospital) $538,173 on August 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, assistance type: Project Grant) to investigate the molecular mechanisms controlling developmental timing through NADH redox metabolism. The project uses a segmentation clock—a molecular oscillator whose period correlates with embryonic development...
- This Project Grant award from the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) federal grant program provides $819,980.00 in funding to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on elucidating sex differences in melanoma tumorigenesis. The 3-year research project, beginning on August 15, 2024 and ending on August 14, 2027, aims to advance the understanding and treatment of this complex...
The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $635,367 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms of cell division and cell signaling. The research addresses how micron-scale microtubule structures organize as signaling scaffolds in cell division and Hedgehog signal transduction. In the cell-division strand, the work focuses on the spindle midzone, examining how the Aurora-B kinase-containing chromosome passenger complex is recruited specifically to midzone microtubules for cytokinesis and characterizing the structure and dynamics of this complex using newly developed human complex purification and tools to study microtubule organization. In the Hedgehog signaling strand, the research investigates cilium-based mechanisms. The research team will employ tirf-microscopy assays, atomic force microscopy, structural methods, and cellular approaches to reconstitute minimal cytoskeletal modules and address fundamental questions about microtubule organization in both systems. The award is structured as a Project Grant with a period of performance from September 1, 2026, through May 31, 2031. Work is performed in Boston, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $635.4k | 8/21/26 |