Project Grant R35GM162432
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts General Hospital a $825,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) on August 7, 2025, with completion scheduled for June 30, 2030. The award funds a five-year research initiative investigating stem and progenitor cell quality assurance mechanisms mediated by macrophages during development and tissue regeneration. The research combines...
- Federal Project Grant Award Summary Florida State University's Sponsored Research Administration Division received a $784,210 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 8, 2025, with completion anticipated by June 30, 2030. The Lazenby Lab will develop aptamer-based biosensing probes integrated into scanned probe microscopy platforms to enable real-time, high-resolution...
- This $125,000 Project Grant award, administered by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to accelerate pharmaceutical biocatalyst development through the deployment of biosensors. Awarded to Harvard Medical School on April 1, 2026, with completion targeted for March 31, 2028, the project addresses critical manufacturing bottlenecks in drug production by developing chemical biosensors...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts Institute of Technology $655,926 under the Biomedical Research and Research Training program (CFDA 93.859) to design and optimize high refractive index proteins for deep tissue imaging in living biological systems. The project, spanning from July 1, 2026 through April 30, 2030, addresses a fundamental limitation in light microscopy—refractive index mismatching between aqueous and lipid...
- Federal Project Grant Award Summary Molecular Instruments, Inc. received a $306,788 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) with an award date of September 30, 2025, and a completion date of September 29, 2026. The award supports the development and advancement of probe technology for ultrasensitive RNA imaging utilizing Hybridization Chain Reaction (HCR) methodology. The project...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts General Hospital a $814,355 Project Grant on August 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support research through June 30, 2029. The project investigates the molecular mechanisms of heterochromatin formation, specifically examining how eukaryotic cells establish and maintain heterochromatin demarcation through histone H3 lysine 9...
- Federal Project Grant Award Summary The University of Washington's Office of Sponsored Programs received a $891,007 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026, with completion targeted for February 28, 2031. The award funds development of next-generation multiplexed optical sensors for quantitative redox phenotyping in human induced pluripotent stem cell...
- Federal Grant Award Summary Harvard Medical School received a $540,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 10, 2025, with completion targeted for August 31, 2030. The award funds expansion of MicroTutor, an online educational platform designed to address critical workforce gaps in quantitative bioimaging and bioimage analysis training. The platform leverages...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded $430,109 to Lawrence Berkeley National Laboratory, a federally funded research and development center operated by The Regents of the University of California, for a project titled "Deeply Subwavelength Near Infrared Imaging with Avalanching Nanoparticles." The award, initiated June 1, 2026, and extending through...
- Federal Project Grant Award Summary Michigan Technological University received $383,801 from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) for a five-year project spanning May 1, 2026, through February 28, 2031. The award funds development of a cost-effective, scalable, multiplexed biosensing platform based on molecularly imprinted polymers (MIPs) for rapid biomarker detection. The research addresses clinical...
The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts General Hospital $444,000 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026, to develop secreted genetically encoded fluorescent biosensors (GEFBs) for in vivo extracellular imaging applications through March 31, 2031. The project delivers a toolkit of biosensor technologies designed to enable real-time visualization of physiological and pathological processes in the extracellular space across four primary research domains: imaging extracellular matrix (ECM) structures and remodeling patterns through fluorescent protein-lectin conjugates; characterizing ion concentrations, oxygen, and redox states in interstitial fluid (ISF) through spatial molecular mapping; monitoring cellular death processes and differentiating between apoptosis and necrosis pathways using genetically encoded fluorescent markers; and providing novel drug screening and diagnostic platforms applicable across multiple tissue types and model organisms. This project advances fundamental biomedical research by addressing a significant gap in GEFB technology development—the limited availability of biosensors specifically engineered for delivery into extracellular compartments. The secreted biosensor toolkit represents a platform technology with broad applicability for translational research and diagnostic development, positioning Massachusetts General Hospital's Research Management Division to deliver innovation in molecular imaging and cellular analysis capabilities.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.0k | 6/23/26 |