Project Grant R01GM155466
- The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), received a $1,485,000 Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award period runs from September 1, 2025 to August 31, 2028. The grant supports research focused on the discovery and characterization of programmable biological systems, particularly new RNA-guided functions found in...
- This $453,750 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the crosstalk between one-carbon metabolism, S-adenosyl-methionine (SAM) availability, and chromatin methylation. The project aims to provide innovative insights into how cells...
- This federal Project Grant award for $412,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training program, supports a research program to improve the interpretation of rare genetic variants. The awardee, The General Hospital Corporation doing business as Massachusetts General Hospital (MGH), will use state-of-the-art computational methods to enhance existing annotation tools for predicting the impact of...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- This federal Project Grant award, valued at $453,750.00 and effective September 1, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research program led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to advance the understanding of perioperative neurocognitive disorders (PND) and their association with disruptions in...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This Project Grant award of $623,120.00 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to investigate pharmacological degradation of two chromatin-regulating proteins, CBP and P300, as a potential therapeutic strategy for treating multiple myeloma. The key objectives are to: Use CBP/P300 inhibitors and degraders to assess the comparative effects of disrupting these proteins in multiple myeloma cells through epigenomic, transcriptomic, and chromatin...
- This $445,000 federal project grant was awarded on January 23, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research conducted by the Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California, to elucidate the molecular mechanisms by which protein arginine methylation regulates gene expression, RNA metabolism, and human biology and...
- This $148,568 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program will support research to elucidate the role of chromatin structures in genomic imprinting. The project, led by Harvard University, aims to investigate the regulatory mechanisms and functional implications of allele-specific chromatin structures in the regulation of the MEST-COPG2 imprinted domain, which is associated with...
The National Institute of General Medical Sciences (NIGMS) awarded a $408,367 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), under the Biomedical Research and Research Training program (CFDA 93.859). The grant, with a performance period from August 15, 2025 to June 30, 2029, supports research to define an RNA-independent mechanism for the nucleation of heterochromatin formation, a critical process for maintaining genomic stability. The project builds on prior work by the research team, who identified an alternative pathway involving the nuclear RNA quality control complex MTREC that recognizes a heterochromatic long non-coding RNA and interacts with the histone H3 lysine 9 methyltransferase CLR4 to initiate heterochromatin assembly. This foundational research has potential long-term implications for understanding the molecular underpinnings of diseases associated with the loss of heterochromatin, such as cancer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.4k | 8/15/25 |