Project Grant R01GM164515
- Federal Grant Award Summary Massachusetts Institute of Technology received a $3.93M Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 15, 2025, with a completion date of July 31, 2029. The project develops high-throughput quantitative phase microscopy (QPM) technology using customizable nano-optics to overcome electronic hardware bottlenecks in imaging cytometry. The core...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $269,071 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through June 30, 2031. Under this R35/MIRA (Maximizing Investigators' Research Award) grant, MIT will develop and advance cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) methodologies to visualize and...
- Federal Project Grant Award Summary Massachusetts Institute of Technology (MIT) received a $440,465 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through February 28, 2031. The award supports fundamental biophysical research aimed at understanding chromosome architecture and its mechanisms—specifically motor-driven loop extrusion and affinity-driven...
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $149,264 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through September 24, 2028. The award funds structural investigations into the regulatory states of human ribonucleotide reductase (RNR), a critical metalloenzyme responsible for de novo deoxyribonucleoside triphosphate (dNTP)...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $327,085 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2026. The award supports fundamental research to develop innovative chemical and molecular tools for investigating human lectin function and their interactions with glycan structures on cellular surfaces. The...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $150,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), with an award date of March 5, 2026, and completion date of November 15, 2027. The Wendlandt Group will conduct fundamental research on the deracemization of alpha-carbonyl stereocenters using stereoselective hydrogen atom abstraction (HAA) with chiral...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $438,788 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026 through June 30, 2031. The award supports fundamental research investigating how pathogenic microorganisms manipulate eukaryotic cellular membranes, with particular focus on understanding the regulatory mechanisms controlling micron-scale...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts Institute of Technology a $1,082,800 Project Grant on August 4, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate adaptive evolution and colonization dynamics within human microbiomes. The research will employ high-throughput culture-dependent genomic methods to characterize within-person evolutionary processes across multiple bacterial...
- Federal Grant Award Summary Massachusetts Institute of Technology (MIT) received a $450,000 Project Grant award from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective August 1, 2025, through July 31, 2028. This renewal award funds the development of computational and theoretical methods for designing molecular recognition systems that mimic antibody functionality in synthetic sensors...
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $325,000 project grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective August 1, 2025, through July 31, 2028. This collaborative research initiative will develop 3D-integrated micro-photometer chips designed to advance in vivo deep-brain fluorescence imaging for neuroscience research. The...
Massachusetts Institute of Technology received a $655,926 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through April 30, 2030. The award supports research designed to develop and optimize high refractive index (RI) proteins for enhanced deep tissue imaging in living biological systems. The project addresses a critical limitation in light microscopy—light scattering caused by refractive index mismatching between aqueous and lipid cellular components—which prevents visualization of dynamic biological processes occurring deep within intact tissues. The research deliverables encompass three integrated aims: (1) artificial intelligence-driven design of synthetic high RI proteins; (2) systematic characterization of approximately 50-100 protein candidates using a custom, scalable laboratory pipeline; and (3) advancement of approximately 15 high-priority candidates for safety testing and genetic delivery validation in three-dimensional living tissue systems. The project leverages MIT's multidisciplinary expertise in synthetic protein design, gene expression and delivery, and optical imaging methodology. By employing genetic encoding of RI proteins rather than traditional clearing agents limited to fixed samples, the research aims to enable tunable spatiotemporal expression of imaging agents while preserving living tissue viability, thereby advancing biomedical imaging capabilities for complex biological research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $655.9k | 6/19/26 |