Project Grant R35GM161787
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded a $849,969 Project Grant to the University of Cincinnati on August 1, 2025, under the Biological Sciences program (CFDA 47.074) to conduct fundamental research on microtubule lattice allostery and protein-protein interactions. The four-year research initiative (through July 31, 2029) employs multi-scale computational modeling, machine learning, and experimental...
- Federal Grant Award Summary The University of California, San Francisco received a $501,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 5, 2025, with completion expected May 31, 2030. This five-year research initiative focuses on bridging the gap between predicted and experimentally determined atomic structures in structural biology. The project will develop...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded $150,104 to the University of California, San Francisco on August 8, 2026, for a Project Grant focused on de novo protein design. The research aims to engineer allosterically regulated proteins capable of intramolecular signal transduction—a fundamental process governing central metabolism, genetic regulatory networks, and...
- Federal Grant Award Summary The University of Miami received a Project Grant award of $501,165 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, with completion targeted for January 31, 2031. The award funds fundamental research into the structure and dynamics of macromolecular complexes, specifically focusing on three human membrane proteins with significant implications for...
- Federal Grant Award Summary The University of California, Davis received a $432,417 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with a completion date of January 31, 2031. This award supports fundamental biomedical research investigating how linear and nonlinear mechanical forces within the extracellular matrix regulate cellular metabolism through...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $1,020,780 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on May 10, 2025, with a completion date of March 31, 2030. The research project, titled "Mechanisms of Homeodomain Transcription Factor Specificity," delivers fundamental biomedical research aimed at understanding how...
- Federal Project Grant Award Summary The University of California, San Diego received a $327,019 Project Grant award dated July 25, 2025, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research through April 30, 2030, focusing on developing innovative biophysical and computational frameworks to understand how cells transform during embryogenesis and stem cell differentiation. The...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC San Diego a $249,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2025 through August 31, 2028. This award supports fundamental research to advance understanding of how biophysical cues shape macrophage and T-cell functions in the context of inflammation and cancer. The research deliverables include the development and...
- Federal Grant Award Summary The University of California, Davis received a $431,614 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2030. This award funds fundamental research investigating the regulatory mechanisms governing alpha/beta tubulin biogenesis and polymerization, with specific focus on how tubulin cofactors and microtubule polymerization...
- Federal Project Grant Award Summary Duke University received a $482,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through February 28, 2031. The award funds the development of computational methods and workflows to advance single-particle cryo-electron tomography (SP-cryo-ET), a cutting-edge imaging technology for visualizing protein structures within cells...
The University of Cincinnati received a $756,933 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 15, 2026, with completion targeted for February 28, 2031. The award funds fundamental structural and functional characterization research of transforming growth factor-beta (TGFβ) superfamily signaling and regulation. The research employs integrated methodologies including cryo-electron microscopy (cryo-EM), X-ray crystallography, hydrogen-deuterium exchange mass spectrometry (HDX/MS), cell-based signaling assays, and computational biology approaches to investigate ligand-receptor interactions, prodomain-mediated regulation, heterodimer formation mechanisms, and antagonist-ligand binding mechanisms across the TGFβ ligand family. The research program delivers scientific products and knowledge outputs addressing four primary research questions: variations in ligand-receptor interactions supporting selectivity; prodomain regulation of corresponding ligands; molecular mechanisms enabling heterodimer formation and differential receptor interactions; and structurally dissimilar antagonist binding and modulation mechanisms. The research incorporates emerging deep learning and artificial intelligence technologies to enhance de novo protein design strategies. This multi-faceted research initiative aims to advance fundamental understanding of molecular mechanisms governing TGFβ family signaling, with direct implications for elucidating disease pathogenesis and informing therapeutic development strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $756.9k | 4/8/26 |