Project Grant R35GM161714
- Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Dartmouth College a Project Grant of $408,750 under the Biomedical Research and Research Training program (CFDA 93.859) on June 1, 2026, with completion targeted for January 31, 2031. This award funds fundamental research characterizing heme enzymes and their conformational and redox properties in bacterial systems, with emphasis on understanding electron transfer mechanisms in oxygen-limited and anaerobic...
- Federal Project Grant Summary The National Institute of General Medical Sciences (NIGMS) awarded Dartmouth College $2,252,479 under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through July 31, 2029. This R35 Maximizing Investigators' Research Award funds fundamental research investigating the mechanisms by which protein glycosylation regulates cell fate specification. The research employs zebrafish embryo models and loss-of-function studies to...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Trustees of Dartmouth College $1,317,220 under the Biomedical Research and Research Training program (CFDA 93.859) for a four-year project spanning March 1, 2026 through February 28, 2030. The award funds basic research investigating the mechanisms of SWI/SNF (Switch/Sucrose Non-Fermentable) complex chromatin targeting selectivity—a multi-subunit, adenosine triphosphate (ATP)-dependent...
- Federal Grant Award Summary Dartmouth College received a $2.25 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2029. The award supports the development of novel computational methods to decode disease mechanisms by reconstructing cellular proliferation, differentiation, and migration events from single-cell sequencing data. This...
- Federal Grant Award Summary Dartmouth College received a $125,888 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective July 1, 2025 through June 30, 2027. This collaborative research initiative supports the development of photonic-integrated-circuit two-photon (PIC-2P) microscopy technology designed to advance deep-tissue imaging capabilities. The primary...
- Federal Project Grant Award Summary Dartmouth College received $883,252 in federal funding from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year research initiative (September 1, 2025 – June 30, 2030) titled "Understanding the Role of Anesthesia in Perioperative Organ Injury via Wireless Soft Implants." The project addresses a significant clinical gap in understanding...
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $3.93M Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 15, 2025, with a completion date of July 31, 2029. The award funds development of high-throughput end-to-end design of quantitative phase microscopy based on customizable nano-optics to overcome electronic hardware bottlenecks limiting...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts Institute of Technology $655,926 under the Biomedical Research and Research Training program (CFDA 93.859) to design and optimize high refractive index proteins for deep tissue imaging in living biological systems. The project, spanning from July 1, 2026 through April 30, 2030, addresses a fundamental limitation in light microscopy—refractive index mismatching between aqueous and lipid...
- Federal Grant Award Summary Harvard Medical School received a $540,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 10, 2025, with completion targeted for August 31, 2030. The award funds expansion of MicroTutor, an online educational platform designed to address critical workforce gaps in quantitative bioimaging and bioimage analysis training. The platform leverages...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Dartmouth College $2.77 million under the Biomedical Research and Research Training program (CFDA 93.859) on August 8, 2025, to establish a Center for Implementation Science through the Centers of Biomedical Research Excellence (COBRE) mechanism. This project grant, obligating funds through May 31, 2030, supports the development of a multidisciplinary research program dedicated to advancing...
The National Institute of General Medical Sciences (NIGMS) awarded Dartmouth College $408,750 under the Biomedical Research and Research Training program (CFDA 93.859) on July 1, 2026, for a five-year project through June 30, 2031. This Modular R01 Award for Independent Scientists (MIRA) grant supports the development of photoswitchable hydrazone-based fluorescent dyes designed to advance super-resolution microscopy (nanoscopy) capabilities. The research addresses a critical gap in molecular imaging by creating bistable hydrazone switches that can be toggled on and off using different wavelengths of light, enabling real-time, three-dimensional visualization of biological processes at the molecular level. The proposed fluorophores combine high absorption coefficients, strong emission quantum yields, brightness, and ease of synthesis and derivatization in a structurally simple platform—properties that position them as competitive alternatives to existing protein-based or organic dye-based photoswitchable fluorophores currently used in super-resolution microscopy applications. The project will be conducted at Dartmouth College's campus in Hanover, New Hampshire, through the Office of Sponsored Projects. By overcoming current limitations in photoswitchable dye performance—including photobleaching, low contrast ratios, poor biocompatibility, and limited quantum yields—this research aims to transform nanoscopy into a practical tool for visualizing fundamental biological processes in live specimens and cellular environments, including human HeLa cells and serum solutions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.8k | 7/1/26 |