Project Grant R35GM161380
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UCLA a $433,125 Project Grant effective July 1, 2025, through April 30, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research investigating histone H3 as a copper reductase enzyme—a novel enzymatic function that catalyzes the reduction of cupric (Cu2+) to cuprous (Cu1+) ions. The research challenges the traditional view of...
- Federal Grant Award Summary Under the Biomedical Research and Research Training program (CFDA 93.859) administered by the National Institute of General Medical Sciences, the University of Houston System received a Project Grant award of $435,412 effective September 1, 2025, with a completion date of August 31, 2027. Principal Investigator Dr. Yu Liu will develop TO-Triplex-Seq, a novel whole-genome sequencing technology designed to identify and characterize RNA-DNA triple helix formations at...
- Federal Project Grant Award Summary The University of Colorado received a $238,819 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2028. The award funds fundamental research investigating the regulation of zinc-dependent lysosome morphological restructuring, zinc trafficking, and low zinc homeostasis mechanisms across Caenorhabditis elegans...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $390,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with completion scheduled for December 31, 2030. This research project investigates inter-organelle unfolded protein response (UPR) coordination and cellular proteostasis, specifically examining how cells maintain...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $390,000 Project Grant award effective August 1, 2025, through June 30, 2030, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). This award funds fundamental research investigating tissue-specific regulation of autophagy by proppins (B-propellers that bind phosphoinositides), specifically the WIPI1-WIPI4 protein...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $577,500 to the University of North Carolina at Charlotte through the Biomedical Research and Research Training program (CFDA 93.859) for a three-year project (September 1, 2025–August 31, 2028) investigating the mechanistic regulation of the copper chaperone for superoxide dismutase (CCS) protein. The research addresses fundamental gaps in understanding how post-translational phosphorylation...
- Summary of Federal Grant Award The University of Texas Health Science Center at Houston has been awarded $868,584 under the Biomedical Research and Research Training program (CFDA 93.859), administered by the National Institute of General Medical Sciences within the National Institutes of Health. The project grant, effective from September 1, 2025, through August 31, 2027, supports fundamental research investigating how ribonucleic acid (RNA) modifications regulate adaptive messenger RNA...
- Federal Project Grant Award Summary The University of Houston System received a $431,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 6, 2025, with completion targeted for July 31, 2030. The award funds a comprehensive research initiative titled "Hypertensive Toads: Investigating the Physiological and Evolutionary Pathways to Salt Tolerance in...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences (CFDA 47.074 – Biological Sciences program) awarded the University of Houston System a Project Grant of $332,385 effective September 1, 2025, through August 31, 2028. This research initiative focuses on identifying host-encoded RNA binding proteins that promote P-element transposition in Drosophila melanogaster. The project will develop genetic reagents for controlled expression...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $335,400 Project Grant award, effective September 1, 2025, through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on phosphatidylserine (PS) synthesis, trafficking, and its role in cellular cholesterol homeostasis. The research project will be completed by May 31, 2029, and focuses on...
The University of Houston System received a $431,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through March 31, 2031. This five-year research initiative focuses on elucidating the mechanisms by which copper transporter 1 (CTR1) transitions between oligomeric states to regulate copper homeostasis and support neuronal development. The project will deliver fundamental biomedical research products including mechanistic insights into CTR1's dynamic oligomerization, utilizing advanced single-molecule assays such as single-molecule localization microscopy and in-cell oligomer stoichiometry assays to visualize and quantify CTR1 states in situ within human embryonic stem cell-derived neurons. The research will produce comprehensive proteomic and biochemical analyses identifying key protein interaction networks that modulate CTR1 trafficking and function, with particular emphasis on CTR1's interactions with LALOO and SNT1 proteins in regulating neuronal maturation. This multidisciplinary effort addresses two primary research directions: characterizing the triggers for CTR1's transition from trimeric to monomeric forms under excess copper conditions, and exploring CTR1's functional role in stem cell differentiation. The project outcomes will advance understanding of how copper-induced allosteric changes in CTR1 oligomerization influence neuronal health and development, laying foundational knowledge for potential advances in diagnosing and treating copper deficiency-related developmental disorders.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.8k | 3/19/26 |