Project Grant R01GM158922
- This federal Project Grant award of $394,214 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the intracellular transfer of lipids between cell membranes. The grant, awarded to Oregon Health & Science University (OHSU), aims to characterize the lipid transport function of two specific proteins, MPP6 and ATP11A, and determine their 3D structures using cryo-electron microscopy. The...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $390,000.00 to the University of Texas Health Science Center at Houston (UTHealth) for research focused on understanding how "proppins" (B-propellers that bind phosphoinositides) differentially regulate basal autophagy, a key cellular process, across distinct tissue types and developmental stages. The research...
- This federal Project Grant award of $416,398 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research on the regulation of neutral lipid metabolism in eukaryotes. The research program at Texas A&M AgriLife Research, a component of the Texas A&M University System, aims to elucidate the underlying mechanisms controlling the enzymatic activity of acyltransferases...
- The Project Grant award in the amount of $778,444.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at understanding the structure and function of phospholipids and inositol phosphates in the cell nucleus. The research, conducted by a diverse group at Vanderbilt University Medical Center, focuses on investigating the structural biology and functional genomics of these...
- The University of Texas Southwestern Medical Center received a $300,000 Project Grant from the National Institute of General Medical Sciences' Biomedical Research and Research Training program to support research on the biophysical study of endoplasmic reticulum (ER) protein recognition for degradation and lipid homeostasis. The award period is from April 1, 2021 through March 31, 2022. The grant will fund research to elucidate the molecular and biophysical mechanisms underlying the targeted...
- The University of Texas Health Science Center at San Antonio (UTHSCSA) was awarded a $385,639 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant funds research aimed at uncovering the molecular details behind synaptic transmission, with a focus on understanding the structure and function of AMPA receptor complexes in the brain. The research project, scheduled to run from September 1,...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $428,255.00 to Pennsylvania State University to investigate the structural and molecular mechanisms for the recognition of membrane geometry and the translation of membrane geometry into protein function. The key objectives of this 5-year research project, which runs from August 8, 2025 to July 31, 2030, are to...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms of lipid droplet protein targeting. The project aims to determine how proteins are targeted to and removed from lipid droplets in human cells, with a focus on understanding the structural basis and physiological...
- This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule...
- This $376,250 Project Grant was awarded on May 5, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to characterize the metabolism and quantification of specialized pro-resolving lipid mediators (SPMs), which play important roles in the resolution of inflammation. The project aims to identify and understand the pathways by which SPMs are transformed in the human body, with...
This $335,400.00 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Texas Health Science Center at Houston (UTHealth). The grant supports fundamental scientific research to investigate the synthesis, trafficking, and regulation of the lipid phosphatidylserine (PS) and its interplay with cellular cholesterol homeostasis. The research aims to determine the structures of the PS synthase enzymes PSS1 and PSS2, examine the role of TMEM41B and VMP1 in cholesterol transport, and elucidate how cholesterol regulates the targeting and interactions of the PS transport proteins ORP5 and ORP8. The ultimate completion date for the research project is May 31, 2029. This work is expected to provide innovative insights into the mechanisms governing the relationship between PS and cholesterol, with potential implications for advancing the understanding and treatment of diseases involving lipid dysregulation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $335.4k | 8/19/25 |