Project Grant R35GM161372
- Federal Project Grant Award Summary Indiana University received a $446,435 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective September 4, 2025, with completion targeted for June 30, 2029. The grant supports fundamental research into the mechanisms of pterin-dependent regulation in proteobacterial systems, specifically investigating how bacteria transition from free-living to biofilm...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $435,875 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 9, 2025, with completion targeted for July 31, 2030. This award supports fundamental biomedical research investigating the coding and noncoding molecular mechanisms of a bifunctional gene across multiple cellular contexts. The...
- Federal Project Grant Award Summary Indiana University Indianapolis received a $396,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through February 28, 2031. The award funds fundamental research to decode the structural and molecular architecture of centriolar plaques (CPs), non-centrosomal microtubule organizing centers involved in atypical eukaryotic cell...
- Federal Project Grant Award Summary The National Science Foundation's Division of Integrative Organismal Systems awarded Indiana University $427,981 under the Biological Sciences program (CFDA 47.074) on October 15, 2025, for a collaborative research project titled "Advancing CRISPR Approaches for Bacterial Functional Genomics Applied to Marine Vibrio-Host Interactions." The project, which extends through September 30, 2028, will develop and advance CRISPR-based genetic manipulation...
- Federal Grant Award Summary Indiana University Indianapolis has received a $772,026 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. The award supports the development and validation of improved methodologies for conducting in vivo forward genetic screening, a high-throughput functional genomics approach that has been successfully applied in...
- Federal Project Grant Award Summary Purdue University received a $150,104 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 12, 2026, with a completion date of November 16, 2028. The grant supports fundamental research aimed at determining the role of CsoS2 protein in carboxysome assembly and regulation—a critical component of the carbon dioxide concentrating mechanism found in...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $382,026 to Indiana University (Trustees of Indiana University) on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research initiative titled "Target-Specific Dyes with Responsive Long-Lived Fluorescence Lifetimes for Biological Interrogation," with performance through August 31, 2030. The project...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $420,984 to the University of California, Los Angeles to support a five-year research project (August 1, 2025 – July 31, 2030) under the Biomedical Research and Research Training program (CFDA 93.859). The project investigates viral biosensors of host post-translational modifications (PTMs), examining how viruses perceive and respond to host cell cues during infection. The research will...
- Federal Grant Award Summary Indiana University received a $631,989 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 5, 2025, through September 4, 2027. The award supports fundamental research into enantioselective chemical synthesis methods utilizing Lewis base and transition metal catalysis to develop efficient stereoselective reactions. The research objectives focus on...
- Federal Project Grant Award Summary Indiana University (Trustees of Indiana University) received a $370,783 Project Grant award on September 10, 2025, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) to develop an intelligent droplet acoustofluidic platform for automated liquid-liquid handling and monitoring in biomedical research. The project, which runs through August 31, 2029, will integrate digital...
Federal Project Grant Award Summary Indiana University received a $428,857 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with completion targeted for December 31, 2030. The award supports fundamental research investigating the mechanisms of cell dormancy and virus entrapment in spore-forming bacteria, specifically examining how certain viruses have evolved strategies to circumvent bacterial metabolic defenses by hijacking dormancy programs. Using Bacillus subtilis as a model system, the research will employ CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing, single-cell transcriptomics, microfluidic platforms, and artificial intelligence-informed morphological analyses to characterize viral auxiliary genes and their role in viral genome entrapment within bacterial spores. The research deliverables will advance understanding of host-virus coevolution by testing competing models of viral entrapment through quantitative single-cell assays, investigating developmental consequences of entrapment via host-virus expression profiling, and tracking the fate and fitness dynamics of infected spores ("virospores") using microfluidic technology. Results will integrate experimental data with mechanistic models to synthesize findings, contributing fundamental knowledge to molecular biology and microbial genetics with implications for understanding viral persistence mechanisms and bacterial-viral interactions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $428.9k | 3/10/26 |