Project Grant R01GM160733
- This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and their physiological effects in bacteria. The research program will synthesize chemical tools and use in vitro and in cellulo techniques to investigate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on bacterial...
- This federal Project Grant award of $435,875.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the coding and noncoding molecular mechanisms of a bifunctional gene in multiple cellular contexts. The award, with a performance period from September 9, 2025 to July 31, 2030, was granted to the Trustees of Indiana University, doing business as Indiana University...
- This federal Project Grant award of $360,247, granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms underlying the function and regulation of signaling effectors associated with type III CRISPR-Cas systems in microbes. The research aims to advance the understanding of how these RNA-guided immune systems in bacteria and archaea use cyclic nucleotide second...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The $383,746 award, with a performance period from January 1, 2025 to December 31, 2029, will be executed by Cornell University's Office of Sponsored...
- This federal Project Grant award of $382,026.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to synthesize, characterize, and implement a palette of target-specific organic dyes with biologically-responsive long-lived fluorescence lifetimes. The goal is to develop optical reporting dye technology that can yield two long-lived fluorescence lifetimes that are mechanoresponsive,...
- This federal Project Grant award of $348,963.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental scientific research to investigate the mechanisms of quorum signal synthesis in gram-negative bacteria, with the goal of establishing molecular determinants for substrate recognition and developing quorum sensing inhibitors as potential anti-virulence compounds. The...
- The federal Project Grant award of $412,525.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research in the Hundley Lab at Indiana University. The research aims to define the molecular mechanisms that regulate ADAR target recognition and RNA editing, which are essential functions of human ADAR proteins that are dysregulated in over 35 human diseases. The proposed work focuses on understanding...
- This $408,375 federal Project Grant awarded on August 18, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to uncover the rules governing the spread of mobile genetic elements (MGEs) in microbes. The project aims to characterize MGE compatibility and how MGEs and microbial chromosomes co-evolve to maintain compatibility, using plasmids in the Agrobacteria/Rhizobia complex as a model...
- The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $433,459 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to the University of Kansas Center for Research Inc. The grant supports fundamental research to expand the understanding of quorum sensing - a type of cell-cell communication used by bacteria, including many pathogens, to coordinate group behaviors. The research will combine laboratory models with molecular genetic and genomic...
This federal Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $446,435 to support research on the regulatory mechanisms of pterin-dependent signaling in proteobacterial systems. The project, conducted by Trustees of Indiana University (UEI: YH86RTW2YVJ4), will investigate how the cytoplasmic second messenger cyclic diguanylate monophosphate (c-di-GMP) is regulated by the interaction between the DcpA protein and excreted pterin metabolites in the bacterium Agrobacterium tumefaciens. This research aims to further the understanding of biofilm formation and bacterial attachment processes, which have implications for antimicrobial tolerance and pathogenesis. The project will run from September 4, 2025, through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.4k | 9/3/25 |