Project Grant R01GM157347
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- The National Institute of General Medical Sciences (NIGMS) awarded a $422,569 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Vanderbilt University, effective May 1, 2025 through April 30, 2030. The funding supports the development of new reactions and reagents to generate enantioenriched organic compounds that can serve as precursors for medicinal agents and biologically active natural products. The proposed methods target the synthesis of secondary...
- This federal Project Grant award of $620,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project at Boston College focused on "Catalytic Radical Processes for Stereoselective Chemical Synthesis." The research aims to establish metalloradical catalysis as a framework for controlling the reactivity and stereoselectivity of homolytic radical reactions in organic synthesis. The...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding research to develop novel metal complexes based on abundant first-row metalate species for use as catalysts in biomedical and chemical applications. The $147,025 award to the University of California, Merced will support research efforts in two key areas: 1) Investigating the structural and electronic...
- This federal Project Grant award for $874,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on enantioselective and site-selective C-H activation reactions. The key objectives are to develop next-generation ligands capable of enantio- and site-selective C(SP3)-H activation of aliphatic carboxylic acid substrates, as well as to achieve enantio- and site-selective ring...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This federal Project Grant award of $382,026.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to synthesize, characterize, and implement a palette of target-specific organic dyes with biologically-responsive long-lived fluorescence lifetimes. The goal is to develop optical reporting dye technology that can yield two long-lived fluorescence lifetimes that are mechanoresponsive,...
- This federal Project Grant award of $146,816.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to develop general strategies for the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers, a class of medicinally relevant chiral compounds that are difficult to obtain through other methods. The research outlined will employ bioinformatic techniques to...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $552,403 Project Grant to The Trustees of Columbia University in the City of New York. The grant, effective September 1, 2025 through August 31, 2030, will support research to develop innovative methods for the selective synthesis of functionalized amines and heterocycles from common feedstock chemicals. The research aims to address unmet needs in...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding research on enantioselective chemical synthesis methods using Lewis base and transition metal catalysis. The $631,989 award to the Trustees of Indiana University, awarded on September 5, 2025, aims to develop a general, modular, and operationally trivial toolbox of effective stereoselective reactions by leveraging Lewis base and transition metal catalysis, as well as cooperative catalysis, to expedite the design, development, and manufacture of new medicines. The research objectives include introducing novel stereoselective reactions that can address the challenges in the pharmaceutical industry related to the efficient and cost-effective preparation of structurally complex and stereochemically diverse drug candidates.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $632.0k | 9/5/25 |