Project Grant R35GM163971
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $441,375 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanobiology in tissue-mimetic contexts. The recipient's research addresses how cells sense, process, and respond to mechanical signals within their microenvironment, with focus on the viscoelastic properties of the...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $2.255 million under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds development, application, and dissemination of integrative structure modeling methods for computing structural and spatiotemporal models of biomolecular complexes. The recipient will expand the scope of the open-source Integrative Modeling Platform...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $246,263 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into post-transcriptional regulatory networks and the integrated stress response (ISR). The work will comprehensively characterize the cofactors engaged by regulatory RNA-binding proteins and...
- The National Institute of General Medical Sciences awarded $1,324,670 to the Regents of the University of California (operating Lawrence Berkeley National Laboratory) on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to enable time-resolved studies of small molecule-protein interactions with pharmacological relevance using serial crystallography. The research develops methods to follow structural changes in proteins in real time and under...
- The National Institute of General Medical Sciences awarded University of California, Berkeley $206,410 on July 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how AlphaFold2, Google DeepMind's deep learning system for predicting protein three-dimensional structures, has shaped structural biology and downstream biomedical research since its 2021 release. The research pursues three specific aims. Aim 1 examines how AlphaFold2 has affected...
- The National Institute of General Medical Sciences awarded $441,375 to The Regents of the University of California, doing business as University of California, Berkeley, on September 1, 2026, under the R35 (MIRA) program (CFDA 93.859, Biomedical Research and Research Training). The award funds a five-year project investigating how tissues integrate immune-cell derived signals to regulate inflammation, repair, and homeostasis. The research pursues three interconnected directions: dissecting how...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $510,183 under the Biomedical Research and Research Training program (CFDA 93.859) on March 17, 2026. The award supports the Song Lab's development of robust and scalable machine learning and statistical methods for genomics, including computational tools, statistical methods, and machine learning models for understanding evolution and...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of California, Davis $341,970 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop polarizable Gaussian multipole force fields for biomolecular simulations based on in-solution electrostatics. The recipient will develop parameters and simulation methodologies to advance AMBER polarizable force field efforts for proteins, nucleic acids, and drug-like molecules. Work...
- The National Institute of General Medical Sciences awarded the University of California, Merced $400,910 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational modeling of RNA polymerase II elongation complex dynamics. The project uses molecular dynamics simulations and computational techniques including enhanced simulation methods, machine learning, and deep learning algorithms to study the elongation stage of transcription. The...
The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded the University of California, Berkeley $287,221 in project grant funding on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into the molecular dynamics of biomolecules and their interactions, with emphasis on fusing biophysics and machine learning approaches. The work develops rigorous computational models and force fields to simulate protein dynamics and intrinsically disordered proteins and regions (IDPs/IDRs), connecting quantum mechanics calculations to advanced force fields that improve accuracy while remaining computationally affordable. The research will back-calculate experimental observables from solution-based experiments such as NMR near-surface electrostatic potentials, annotate regions of low confidence in AlphaFold2 predictions using deep learning methods based on transformer and diffusion models, and model IDP/IDR complexes with focus on biocondensates across systems ranging from simple arginine and tryptophan sequences to hydrophobic domain repeat units in tropoelastin and alpha-synuclein. Performance occurs at Berkeley, California. The period of performance runs from September 1, 2026, through August 30, 2031. The award is a project grant, classified by NIGMS as a Modular Research Award Investigator (MIRA) mechanism that the Institute prioritizes over traditional R01 awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $287.2k | 8/3/26 |