Project Grant R35GM164174
- The National Institute of General Medical Sciences awarded $429,203 to the University of Wisconsin–Madison on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R35GM161252) to develop optically enhanced NMR methods for high-resolution analysis of biomolecular structure, dynamics, and interactions at sub-micromolar sensitivity under physiologically relevant conditions. The award supports integrated research combining NMR method...
- The National Institute of General Medical Sciences awarded The Medical College of Wisconsin, Inc. $390,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant (R35GM161455) investigating metabolic regulation of immunity in C. elegans. The funded research elucidates how purine nucleotide metabolism regulates intestinal epithelial defense pathways, particularly focusing on intracellular pathogen response mechanisms in the nematode's...
- The National Institute of General Medical Sciences awarded Wichita State University $534,074 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to design, simulate, build, and demonstrate an ultra-sensitive micro-resonator for X-band electron paramagnetic resonance (EPR) spectroscopy. The project addresses a critical limitation in EPR applications: proteins such as metalloproteins, membrane proteins, and G-proteins—which constitute nearly 30 percent of all...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $412,201 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how metabolic microenvironments direct immune cell plasticity and function. The research project develops and applies an organotypic array for culture in live-cell environments (ORACLE), a micropatterned 3D hydrogel platform with functional vasculature that enables spatial and...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $413,001 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational systems for analyzing single-cell and spatial transcriptomics experiments. The recipient will create computational methods to improve downstream analysis of gene-expression data from single-cell and spatial transcriptomics experiments, which measure genome-wide expression in...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $124,929 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on how epithelial architecture regulates amoeboid migration strategies in vivo. The research examines cell migration through tissues, with focus on leukocyte movement within epithelial layers. Work uses intravital imaging in zebrafish to characterize how mechanical confinement drives...
- Federal Grant Award Summary The University of Wisconsin-Milwaukee is receiving $563,880 in federal funding under a Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) through the Biomedical Research and Research Training program (CFDA 93.859). The award, effective September 1, 2025, through August 31, 2028, supports fundamental research into the regulators of the unfolded protein response (UPR) signaling pathway. The research will investigate how the three major...
- The National Institute of General Medical Sciences awarded the University of Wisconsin – Madison $580,507 on May 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms governing midbody remnants in intercellular RNA communication. Over the five-year period of performance through February 28, 2031, the research will characterize the molecular cargo of midbody remnants—large extracellular vesicles released during cell division—across diverse...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of Wisconsin-Milwaukee $572,553 under the Biomedical Research and Research Training program (CFDA 93.859) for a three-year project (September 1, 2025 through August 31, 2028) investigating pleiotropic consequences of mucoid phage resistance in Escherichia coli populations. The research will deliver fundamental scientific knowledge on how bacterial resistance to bacteriophages develops...
- The National Institute of General Medical Sciences awarded the University of Wisconsin - Madison $3.654 million on July 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support the National Center for Quantitative Biology of Complex Systems, which accelerates multi-omic quantitative biology research by providing researchers integrated access to mass spectrometry, lipidomics, and metabolomics technologies for comprehensive proteome, lipid, and metabolite...
The National Institute of General Medical Sciences awarded The Medical College of Wisconsin, Inc., a Project Grant totaling $566,169 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds development of novel site-directed spin labeling electron paramagnetic resonance (SDSL-EPR) technologies and application of these and other biophysical methods to elucidate molecular mechanisms of G protein-coupled receptor (GPCR) signaling selectivity and allostery. The research addresses conformational dynamics in GPCR activation and receptor-transducer interactions, using structural and time-resolved EPR techniques to evaluate mechanisms rooted in conformational dynamics. The work utilizes the beta-2 adrenergic receptor as the primary model system. Performance occurs in Wauwatosa, Wisconsin, with a period of performance through March 31, 2031. The obligated amount is $566,169.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $566.2k | 8/13/26 |