Project Grant K99GM164682
- The National Institute of General Medical Sciences, a component of the National Institutes of Health, awarded The University of Chicago $590,711 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports development of new synthetic methods to accelerate preparation of diverse analogues for medicinal chemistry studies. Over the five-year performance period ending June 30, 2031, the research addresses carbon-carbon...
- The National Institute of General Medical Sciences awarded the University of Chicago $421,293 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support synthetic modeling research in bioinorganic oxidation chemistry led by the Anderson Laboratory. The award funds a synthetic modeling program investigating principles governing the oxidative activity of metalloenzymes. The research synthesizes and leverages molecular model complexes to study emerging...
- The National Institute of General Medical Sciences awarded the University of Rochester $448,196 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop synthetic tools for constructing carbon-nitrogen bonds using N-aryl and N-alkenyl nitrogen intermediates. The research targets the synthesis of nitrogen heterocycles, which are critical structural components in pharmaceuticals and natural products. The project will develop catalytic methods to...
- The National Institute of General Medical Sciences awarded The University of Chicago $602,095 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structure and function of molecular machines involved in protein and RNA modifications. Over the five-year performance period ending June 30, 2031, the laboratory will conduct integrated structural and biochemical studies of three interconnected systems: the ubiquitin-proteasome pathway...
- The National Institute of General Medical Sciences awarded The University of Chicago $226,884 on January 18, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop multiscale computational simulations investigating actin filament branch formation and aging dynamics. The recipient will model the role of ATP hydrolysis and nucleotide state in actin-related protein (ARP) 2/3 complex subunits during branch aging and dissociation. The work focuses on mechanistic...
- The National Institute of General Medical Sciences awarded $338,892 to the University of Illinois on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for organometallic chemistry research on nickel enzymes. The project focuses on developing catalytic and functional mimics of acetyl-coenzyme A synthase (ACS) and [NiFe] hydrogenase through the design of flexible multidentate ligands with mixed hard/soft donor atoms. The research aims to detect and...
- The National Institute of General Medical Sciences awarded The University of Chicago $125,820 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to integrate evolutionary history and biophysics toward combating antibiotic resistance through study of bacterial Na+/H+ antiporters and related proton-coupled transporters. The research targets Na+/H+ antiporters, a diverse family of membrane proteins essential to bacterial stress resistance and virulence...
- The National Institute of General Medical Sciences awarded The University of Chicago $150,104 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms underlying the repeated functional evolution of bioluminescent proteins derived from haloalkane dehalogenases. The research examines how a new catalytic mechanism—monooxygenase-catalyzed light production—repeatedly evolved in distantly related taxa by recruiting...
- Federal Project Grant Award Summary The University of Chicago received a $1,970,835 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 15, 2025, with a completion date of August 31, 2029. This award funds fundamental biomedical research focused on multiscale computational simulation of key biomolecular processes within cells, specifically addressing biological membranes,...
- The National Institute of General Medical Sciences awarded The University of Chicago $410,000 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods enhancing causal inference in genetics and genomics over a five-year period through December 31, 2030. The research addresses confounding and generalizability barriers in Mendelian randomization and single-cell CRISPR screening by creating statistical and machine learning tools...
The National Institute of General Medical Sciences awarded The University of Chicago $124,929 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop improved aminating reagents and photocatalytic amide bond coupling methods for biomedical synthesis. The award funds mechanistic analysis of o-sulfonylhydroxyl amine-derived aminating reagents to establish the mechanism of n-amination of heterocyclic compounds, design safer and more effective aminating reagents for skeletal editing techniques, and extend electrophilic amination reactivity to additional compound classes. The recipient will then apply this expertise to develop a photocatalytic amide bond coupling approach enabled by light activation of catalytic intermediates. The work addresses adoption barriers in medicinal chemistry by replacing highly energetic reagents and stoichiometric activation with safer, more robust, and catalytic protocols that reduce cost and waste. Performance takes place in Chicago, Illinois. The award runs through July 31, 2028. This is a Project Grant providing training in mechanistic analysis and reagent design to complement the investigator's prior experience in catalyst design, computational analysis, and photochemistry.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $124.9k | 7/23/26 |