Project Grant R35GM160143
- This federal Project Grant, awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $621,980.00 to the University of Texas at Dallas to develop "sliding hydrogel-based microparticles as synthetic platelets" for managing traumatic bleeding. The project aims to create a novel hemostatic agent that can be administered intravenously to...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $1,332,516.00 to the University of Texas at Austin to develop synthetic cells that mimic the essential functions of biological platelets. The project aims to create light-activated, programmable synthetic cells that can undergo shape transformation, release biochemicals, and adhere to surfaces in a coordinated manner to promote blood clotting. This work addresses...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training, provides $585,000.00 to the University of Texas at Dallas to pursue innovative strategies and platforms for (a) discovering 'natural product'-like macrocyclic peptides as modulators of biomolecular interactions, and (b) developing biocatalytic strategies for asymmetric synthesis via 'new-to-nature' chemistries. The project builds upon prior...
- This $604,301 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Versiti Wisconsin, Inc. will support research on membrane-cytoskeleton interactions in megakaryocytes and platelets. The research aims to advance the understanding of abnormal platelet production and function, which can pose significant clinical risks including bleeding and thrombotic events. The project will investigate the precise molecular mechanisms...
- This federal Project Grant award for $460,413.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel visible light-induced transition metal-radical hybrid catalytic methodology for regiocontrolled, mild, and exogenous oxidant-free functionalizations of saturated groups. The proposed research seeks to create a platform for controlled, selective functionalization of organic...
- The Case Western Reserve University (CWRU) received a $121,003 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the atomic-level structural and functional characteristics of platelet membrane proteins. The research aims to leverage cutting-edge cryogenic electron microscopy (cryo-EM) techniques, including the Build and Retrieve (BAR) method and cryo-focused ion beam (cryo-FIB) sample preparation, to...
- This Project Grant award of $375,306 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance personalized transfusion medicine by identifying optimal procedures to yield platelet products with maximum hemostatic capacity. The key products or services to be delivered include: Identifying the thiol redox status of cold-stored platelets compared to room temperature-stored platelets, and the specific redox switches associated with improved...
- This Project Grant award of $506,803, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), will fund research by the Research Foundation for the State University of New York (RF SUNY) to develop advanced multiscale modeling capabilities for predicting thrombus (clot) formation and its response to external loads. The goal is to create computational tools that can better forecast clot growth and rupture under varying blood flow conditions, such as pulsatile...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), provides $504,644 to Bloodworks, a non-profit organization in Seattle, to investigate the relationship between platelets and CD8+ T cells in sepsis. The goals of the 5-year research program are to: 1) determine if platelet-CD8+ T cell aggregates are present in sepsis patients and associated with adverse outcomes, 2)...
- This federal Project Grant award of $552,413.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to Thomas Jefferson University's Sidney Kimmel Medical College. The grant will support research over a period of 4 years, from April 1, 2025 to January 31, 2029, with the goal of investigating siRNA-mediated in vivo knockdown of key regulators of platelet and megakaryocyte function, including the P2Y12 receptor,...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $363,480.00 to the University of Texas at Dallas to conduct research on engineering platelets for therapeutic applications. The project aims to: (1) perform fundamental studies to understand how platelets interact with and internalize different synthetic materials, and (2) develop materials-based tools for engineering platelets through either intra-platelet gene delivery or surface modifications. The research emphasizes engineering polymers with different architectures to evaluate their ability to deliver genes into platelets and identify efficient pathways for genetic modification. As a proof-of-concept, the project will investigate how the dynamic topology of polyrotaxanes can facilitate efficient, stress-free surface binding to platelets. The award period is from August 1, 2025, to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $363.5k | 7/25/25 |