Project Grant R01HL178566
Award Date
8/1/25
Completion Date
4/30/29
Dollars Obligated
$604K
Federal Agency
National Heart Lung and Blood Institute
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Wauwatosa, WI 53226, USA
Similar Awards
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $420,600 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to the University of Colorado-Denver. The grant's objective is to design elastic hydrogel microparticles as a platform to measure key elements of platelet function, including adhesion, activation, aggregation, and contraction. This innovative "lab-on-a-particle" approach aims to improve the reliability and reproducibility of platelet function...
This Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $121,003.00 to Case Western Reserve University to conduct research on the atomic-level structural-omics of platelet membrane proteins. The research aims to solve the structures of platelet membrane proteins in their native environment using advanced cryogenic electron microscopy (cryo-EM) techniques. This includes determining the in-situ...
This $718,854 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to Versiti Wisconsin, Inc., a non-profit blood center and research organization. The award supports research to elucidate the cellular mechanisms governing the non-conventional signaling function of the α5β1 integrin in the formation of tunneling nanotubes (TNTs) and inflammation in blood and endothelial cells. The...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $151,523 to The Medical College of Wisconsin, Inc. to investigate the role of fibrinogen in regulating inflammation and thrombus resolution in acute and chronic venous thrombosis. The research aims to develop a novel RNA therapy using lipid nanoparticles to selectively reduce circulating fibrinogen levels and elucidate its impact on thromboinflammatory processes....
This Project Grant award of $1,276,908 from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research, will support advanced research by Bloodworks, a non-profit organization based in Seattle, Washington. The research aims to increase understanding of the mechanisms of disease in von Willebrand disease and sickle cell disease, which both involve the von Willebrand factor. Key focus areas include investigating the impact of VWF cleavage fragments...
This federal Project Grant award of $1,127,798 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to understand the role of macrophages in preserving cardiovascular health and their contributions to cardiovascular disease (CVD). The overarching goal is to identify new therapeutic targets for CVD in both female and male patients. The research will use advanced single cell imaging and omics techniques to characterize harmful...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,332,404 to The Medical College of Wisconsin, Inc. to investigate the role of basolateral endothelial cilia in promoting vascular stability in the brain. The research aims to evaluate the localization of platelet-derived growth factor-BB (PDGF-BB) in the context of the extracellular matrix and basolateral endothelial cilia, investigate the role of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $465,000 in funding to Bloodworks, a non-profit organization based in Seattle, WA. The award supports research into the mechanisms by which chronic inflammation disrupts hemostatic function in sickle cell disease (SCD). Specifically, the project aims to investigate how TNF-driven inflammation in SCD blocks autophagy and mitophagy in...
This Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research into the role of low-density lipoprotein (LDL) in hemostasis and its potential impact on hemophilia A, a hereditary bleeding disorder. The primary objectives are to: 1) Test the hypothesis that LDL associates with Factor VIII-von Willebrand Factor and improves hemostasis; 2) Evaluate if LDL extends Factor VIII half-life with slower clearance; and 3)...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $693,423 to Baylor College of Medicine to develop and validate a microfluidic device for purifying platelets for pediatric and neonatal transfusions. The goal is to create a simple-to-use, disposable device capable of removing contaminants while preserving the highest-functioning platelets, in order to reduce transfusion-related...