Project Grant R35GM160360
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $418,750.00 to The Feinstein Institutes for Medical Research to conduct research on T cell receptor-mediated T cell activation in neonatal and pediatric sepsis. The goal is to gain insight into how T cell memory influences sepsis-associated organ dysfunction, by comparing responses between human neonates with sepsis and...
- This Project Grant award, valued at $465,000.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The funding supports research to investigate the mechanisms by which chronic inflammation disrupts the hemostatic balance in sickle cell disease (SCD). Specifically, the project aims to understand how tumor necrosis factor-alpha (TNFa) induced inflammation blocks autophagy and mitophagy in platelets and...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Temple University provides $683,299 to conduct research on the functional immune phenotypes of sepsis patients. The project aims to integrate microphysiological assays, omics data, and in silico modeling to better understand how different neutrophil subpopulations and their interactions with the vascular endothelium contribute to sepsis-induced organ dysfunction....
- This Project Grant award of $455,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decrease sepsis mortality in the pediatric population. The key products and services to be delivered include: Developing an AI-guided early sepsis identification tool to enable timely diagnosis and treatment. Performing sepsis phenotyping and creating digital twin patient models to predict personalized treatment responses....
- This federal Project Grant award of $423,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, aims to address two critical challenges related to burn sepsis: Identifying distinct immune response phenotypes after burn injury and their relation to sepsis development, in order to enable novel approaches to mitigate sepsis risk. Determining the mechanism by which elevated angiopoietin-2 (ANGPT-2) leads...
- This Project Grant award, in the amount of $187,410, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant will support Dr. Hilary Faust, an early-career physician-scientist, in developing novel approaches to identify and target sepsis-associated endothelial dysfunction. The funding will enable Dr. Faust to master advanced techniques for modeling human sepsis-associated endothelial injury...
- This $604,301 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to Versiti Wisconsin, Inc. will support research on membrane-cytoskeleton interactions in megakaryocytes and platelets. The research aims to advance the understanding of abnormal platelet production and function, which can pose significant clinical risks including bleeding and thrombotic events. The project will investigate the precise molecular mechanisms...
- This Project Grant award of $392,660 from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) aims to investigate the role of red blood cells (RBCs) in regulating the inflammatory response during sepsis. The key research objectives are to: 1) establish the subcellular localization of Toll-like Receptor 7 (TLR7) in human RBCs and determine their RNA-sequestration capabilities during sepsis, 2) determine how RBC-expressed TLR7 delivers RNA to...
- This $305,000 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a clinical decision support system (CDSS) called Sepsis FLO. The CDSS is designed to precisely guide blood volume diagnosis and treatment for sepsis patients. Key activities include: 1) Developing an alpha prototype of the CDSS through user-centered design; 2) Validating three functional...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $168,048 to Yale University to conduct research on investigating platelet immune mechanisms in sickle cell disease. The primary goals are to 1) characterize heterogeneous platelet subpopulations and their contribution to vaso-occlusive disease in sickle cell patients, and 2) investigate specific immunothrombotic pathways and mechanisms of platelet activation...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), provides $504,644 to Bloodworks, a non-profit organization in Seattle, to investigate the relationship between platelets and CD8+ T cells in sepsis. The goals of the 5-year research program are to: 1) determine if platelet-CD8+ T cell aggregates are present in sepsis patients and associated with adverse outcomes, 2) characterize the involved CD8+ T cell subsets and their functions, and 3) elucidate the molecular mechanisms underlying the platelet-T cell interactions and their impact on CD8+ T cell function during sepsis. This research aims to address critical gaps in understanding sepsis pathogenesis and the role of platelet-mediated CD8+ T cell suppression, with the potential to inform the development of new therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $504.6k | 8/12/25 |