Project Grant R35GM159909
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- This Project Grant award, titled "CAREER: TOWARDS UNDERSTANDING MECHANICAL SIGNALING AT THE CELL MEMBRANE," was provided by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) Federal Grant Program. The award of $805,374 will fund research to uncover the fundamental principles governing how cells sense and respond to mechanical forces at their surface, which is critical to numerous biological functions and human diseases. The project will employ advanced...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically...
- This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
- This Project Grant award of $317,089 from the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) supports the development of new tools to study the dynamics of molecular forces within living cells. The key products and services being delivered under this grant include: Creating a universal tension sensor to measure force loading rates with high resolution, including developing a library of...
- This $398,598 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on mechanosensing mechanisms in intestinal epithelial cells. The principal investigator will use super-resolution functional imaging and in vivo interactomic approaches to identify conserved molecular machineries that drive mechanochemical sensing in epithelial microvilli, investigate physiological...
- This $399,198 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a 5-year research project on the "Dynamics of Cell-Matrix Mechanical Communication During Morphogenesis" at the University of Rochester. The project aims to investigate how mechanical signals from the extracellular matrix modulate cellular mechanisms of remodeling and adhesion to drive tissue-level...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park. The $526,451 grant, awarded on May 1, 2025, supports the development of a novel optical microscopy modality for cell biomechanics research based on pulsed stimulated Brillouin scattering (SBS). The goal is to create a non-contact, non-perturbative, and high-resolution system to study the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a comprehensive research program to decipher the principles and mechanisms of cellular mechanosignaling. The Principal Investigator will leverage a multi-fluorescence biomembrane force probe platform, in combination with molecular/cellular engineering, super-resolution imaging, biophysical modeling, and molecular dynamics simulation, to quantitatively study how single integrin receptors receive, transmit, and transduce mechanical signals. The goal is to identify key structural "hotspots" in integrins that mediate mechanosensitivity, and directionally manipulate integrin mechanosensing to advance the understanding of single receptor mechanosignaling. This 5-year project commences on September 1, 2025 and aims to provide critical training and mentorship opportunities for young scientists in the field of molecular and cellular mechanobiology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 8/27/25 |