Project Grant R35GM157007

Award Date 2/1/25
Completion Date 1/31/30
Dollars Obligated $372K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Madison, WI 53715, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
The National Institute of General Medical Sciences (NIGMS) awarded a $367,105 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Wisconsin - Madison to support research on regional extracellular matrix (ECM) remodeling. The research program aims to increase the rigor and reproducibility of approaches for capturing ECM heterogeneity and its influence on tissue load-bearing function. Key focus areas include developing improved methods for visualizing ECM...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the underlying molecular mechanisms of cellular mechanosensitivity. The $387,662 award to Duke University will enable the development of novel biosensors and techniques to investigate how mechanical forces and protein phosphorylation regulate the mechanical state and force transmission capabilities of key linker...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $440,454 to The Washington University to study epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The project will investigate how epithelial cells sense and respond to extracellular matrix properties, force transmission, and nuclear mechanosensing in the context of processes like wound...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,681 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park (UMD) on February 1, 2025. The grant supports the development of two novel force nanoprobes to map intracellular forces in the genomes of living cells. The first nanoprobe will provide direct quantitative measurements of intracellular forces by converting mechanical stress into...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $526,451 to the University of Maryland, College Park to develop a novel optical microscopy modality for cell biomechanics based on pulsed stimulated Brillouin scattering (SBS). The key objectives are to maximize the throughput of SBS microscopy, validate the modulus estimation from SBS characterization, and field-test the high-speed SBS...
This National Science Foundation (NSF) Project Grant award under the Engineering program (CFDA 47.041) supports basic research to uncover the mechanisms by which mechanical forces at the protein level regulate cell mechanics and direct tissue-scale behaviors. The $616,151 award, with a project period from September 1, 2024 to August 31, 2027, will fund an interdisciplinary study leveraging molecular biology, bioengineering, materials science, and computational approaches. The research will...
The National Institute of General Medical Sciences (NIGMS) awarded a $406,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, with a performance period from January 22, 2025 to December 31, 2029. The grant aims to develop new chemistries and engineering approaches to manipulate the dynamic nascent extracellular matrix within complex...
The National Institute of General Medical Sciences (NIGMS) awarded a $719,606 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Clarkson University. The grant, which runs from Sep 17, 2024 to Jun 30, 2029, aims to advance the visualization and quantification of subcellular and biomolecular mechanics through innovative mechanochemical protocols. The key products and services to be delivered include: 1) Pioneering a comprehensive library of molecular...
This Project Grant award for $479,487 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at The Johns Hopkins University to investigate how key physical cues, such as extracellular fluid viscosity, microenvironmental stiffness, and cellular confinement, regulate cell migration and function. The research aims to develop a comprehensive understanding of how these...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically remodel and interact with viscoelastic extracellular matrices, which is critical for understanding processes like cancer metastasis, immune function, and wound healing. Additionally, the project aims to engineer cells to exert strong forces in viscoelastic environments, which could have implications for improving cancer immunotherapies. The 5-year award period runs from February 1, 2025 to January 31, 2030.

Generated 8/5/25, 5:06 AM