Project Grant R35GM158447
Award Date 9/5/25
Completion Date 5/31/30
Dollars Obligated $501K
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This federal Project Grant award of $294,147 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance modeling of macromolecular interactions in living cells. The key products and services to be delivered through this 5-year project (6/1/2025 - 5/31/2030) include: Characterization of the intermolecular energy landscapes for different types of macromolecules Simulation of macromolecular interactions...
- This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
- This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based...
- The National Institute of General Medical Sciences (NIGMS) awarded a $401,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, Berkeley (UC Berkeley). The grant, with a performance period from September 15, 2025 to July 31, 2030, aims to develop a computational framework that can reliably predict the solubility of drug-related molecular crystals. This effort will involve creating efficient machine learning...
- This $361,283 Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Yale University focused on advancing the fields of molecular structure analysis and molecular dynamics simulations. The research aims to develop novel methods and algorithms that leverage cutting-edge techniques like cryo-electron microscopy and molecular...
- This federal Project Grant award, valued at $404,490.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary awardee, The Regents of the University of Colorado, will use the funding to develop systematically improvable force fields that achieve high accuracy and broad coverage of NIH-relevant chemistry. This work aims to address challenges in modeling protein-ligand binding phenomena...