Project Grant R35GM158408
- This Project Grant award of $223,176 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the structure, function, and mechanism of the carbon monoxide dehydrogenase (CODH) enzyme. Specifically, the award will fund the synthesis and spectroscopic study of biomimetic models of the CODH C-cluster, which is responsible for the enzyme's catalytic activity in carbon dioxide reduction and carbon...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This $244,450 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the catalytic mechanisms, structural dynamics, and biomedical importance of two key classes of metalloenzymes: matrix metalloproteinases (MMPs) and iron(II)/2-oxoglutarate (2OG)-dependent oxygenases. The project, spanning July 2025 to June 2030, aims to provide missing knowledge on these...
- This $138,459 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to uncover the function and protein subcellular localization of bicistronic loci in the green alga Auxenochlorella protothecoides. The research aims to use gene replacement methods to create mutant strains and compare them to wild-type for phenotyping, including physiological and biochemical...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) to the University of California, Berkeley provides $780,000 in funding to investigate the molecular mechanisms of oxygen-dependent enzymes and develop synthetic mimics. The key objectives are to study a class of oxygen-dependent decarboxylase enzymes that utilize iron, manganese, or mixed metal active sites. This research aims to elucidate the critical oxygen-activated...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This federal Project Grant award for $874,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on enantioselective and site-selective C-H activation reactions. The key objectives are to develop next-generation ligands capable of enantio- and site-selective C(SP3)-H activation of aliphatic carboxylic acid substrates, as well as to achieve enantio- and site-selective ring...
- This federal Project Grant award of $151,040.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley. The funding supports research to develop supramolecular photocatalysts that can enable novel photochemical reactions to produce oxygen- and nitrogen-containing heterocycles in a highly selective...
- This federal Project Grant award, valued at $287,488 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a multi-year research initiative to deeply understand how proteins occupy conformational ensembles to enable biological functions. The overall goal is to develop strategies to computationally design new, functional protein ensembles from scratch, with a focus on engineering protein...
- This federal Project Grant award for $678,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular mechanisms governing the assembly of eukaryotic ribosomes. The research aims to define the co-transcriptional assembly events and transitions towards stable post-transcriptional nucleolar assembly intermediates of ribosomal subunits, leveraging advanced...
This federal Project Grant award of $346,634, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into the molecular mechanisms and structural factors governing the reactivity and selectivity of alkane hydroxylase (AlkB), a class-III diiron enzyme family. The research program at Barnard College aims to elucidate the structure-function relationships of AlkB enzymes, which catalyze a diverse range of reactions including the hydroxylation of alkanes, fatty acids, and sphingolipids. Key focus areas include mechanistic studies on AlkB variants, spectroscopic characterization of the active site, and the development of a library of AlkB mutants to probe the structural determinants of reactivity. The research is expected to generate insights into the unusual active site structure and electron transfer mechanisms of this enzyme family, with potential implications for understanding their diverse catalytic functions and enabling bioremediation of oil-contaminated environments. The project is scheduled to run from September 2025 through June 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $346.6k | 8/7/25 |