This $1,590,000 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to develop novel computational modeling methods for understanding the catalytic mechanisms of non-heme iron enzymes. The key objectives are to: 1) create machine learning models to predict the regioselectivity of these enzymes in C-H activation reactions, 2) systematically determine the...
This federal Project Grant award of $147,656 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support advanced spectroscopic characterization of enzymatic intermediates containing iron-sulfur (Fe-S) clusters. The research will utilize electron paramagnetic resonance (EPR) and parahydrogen-induced polarization (PHIP) nuclear magnetic resonance (NMR) techniques, along with isotopic labeling, to study the mechanisms...
This $1,542,569 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is funding the development of new copper-catalyzed chemical reactions to enable the efficient and stereoselective synthesis of chiral amine derivatives and ethers, including saturated heterocycles. The research objectives include exploring reactions for propagating chirality, developing new enantioselective syntheses of...
This federal Project Grant award of $647,301 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance the understanding of iron-sulfur (Fe-S) enzymes. The key objectives are to: Develop synthetic models of Fe-S enzyme intermediates to elucidate their reaction mechanisms and electronic structures. This includes using advanced spectroscopic techniques to characterize the synthetic models and compare...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,116,495.00 to the Regents of the University of California at Riverside to develop sustainable methodologies using earth-abundant nickel-based catalysts for the synthesis of nitrogen-containing compounds. The research aims to enable new chemical reactions for coupling amines and amides under mild conditions, as well as introduce...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $368,110 to the University of Illinois to develop and study biomimetic oxygenase chemistry within peptide-based frameworks. The research aims to obtain detailed structural and mechanistic insights into the function of non-heme iron and copper oxygenase enzymes, which play critical roles in metabolism, natural product...
This Project Grant award, valued at $450,000.00, was provided by the National Science Foundation (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program. The award, effective from August 1, 2024 to July 31, 2027, supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University. The objective of this research program is to elucidate the fundamental mechanisms by which a...
This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $431,400 to North Dakota State University to develop nickel-based catalysts for alkyne hydrofunctionalization reactions. The research aims to leverage directing groups, such as 2-pyridyl moieties, to enhance the efficiency, regio- and stereo-selectivity of nickel-catalyzed alkyne hydroamination and hydroetherification reactions. The project has three...
This $364,324 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the steric and electronic parameters of phosphine (P) catalysts necessary for enantioselective amidation and amide functionalization reactions. The goal is to develop P-catalysts for these transformations, which are important for the synthesis of biologically active compounds. The research will...
The National Institute of General Medical Sciences (NIGMS) awarded a $524,400 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Scripps Research Institute in La Jolla, CA. The grant funds a 5-year research project focused on developing novel catalytic transformations to expedite the synthesis of structurally complex small molecules for drug discovery and development. The project aims to unlock new reactivity modes with earth-abundant metal...