Project Grant R35GM158399
- This federal Project Grant award of $398,444, awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to systematically dissect the contributions of the cellular environment on the polymodal regulation of transient receptor potential (TRP) ion channels. The University of Texas at San Antonio (UTSA) will conduct cell-based experiments and in vitro reconstitution...
- This $408,179 Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The University of Texas Health Science Center at San Antonio (UTHSCSA). The award supports a research program to use state-of-the-art mass spectrometry-based proteomics tools to globally monitor and quantify changes in protein abundance, interactions, and post-translational modifications within the context of the...
- This federal Project Grant award of $574,000, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research and advanced training across diverse areas of biomedical science. The award, with a performance period from May 1, 2025 to Feb 28, 2030, will fund the University of Texas Southwestern Medical Center's research project to understand the general working principles of...
- This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training, provides $585,000.00 to the University of Texas at Dallas to pursue innovative strategies and platforms for (a) discovering 'natural product'-like macrocyclic peptides as modulators of biomolecular interactions, and (b) developing biocatalytic strategies for asymmetric synthesis via 'new-to-nature' chemistries. The project builds upon prior...
- This federal Project Grant award of $1,761,867.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northwestern University. The goal of the award is to establish the National Center for Translational and Developmental Proteomics (NCTDP), which will leverage top-down mass spectrometry methods to optimize and disseminate cutting-edge proteoform discovery and measurement technologies to the...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new chemical strategies for controlling the conformation of bioactive peptides and proteins. The $385,671 award, effective from September 1, 2025 to August 31, 2030, aims to synthesize and evaluate novel amino acid analogs that can influence the secondary structures of peptides and proteins, with the goal...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This federal Project Grant award of $388,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northeastern University. The research aims to develop and validate a new class of engineered macrophages capable of tracking and modulating inflammation in vivo using multi-modal imaging techniques including ultrasound, MRI, and optical imaging. The project will establish a novel framework for...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
This $360,188 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate inflammatory signaling pathways regulated by pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs), using innovative mass spectrometry-based chemical proteomics technology. The research program, led by the University of Texas at Arlington (UTA), seeks to develop new quantitative proteomics methods to dissect the full spectrum of NLR and TLR host-defense signaling pathways, with a focus on understanding the complex interactome networks and post-translational modifications involved in these processes. The award has a performance period from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $360.2k | 8/19/25 |