Project Grant R35GM160160
- This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and their physiological effects in bacteria. The research program will synthesize chemical tools and use in vitro and in cellulo techniques to investigate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on bacterial...
- This $375,420 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural bases for protein synthesis quality control in bacteria. The project aims to elucidate the mechanisms by which translation factors, such as Release Factor 3 (RF3) and Initiation Factor 2 (IF2), monitor the accuracy and fidelity of protein synthesis by the bacterial ribosome. The award,...
- This federal Project Grant award of $574,000, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research and advanced training across diverse areas of biomedical science. The award, with a performance period from May 1, 2025 to Feb 28, 2030, will fund the University of Texas Southwestern Medical Center's research project to understand the general working principles of...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This federal Project Grant award of $404,569.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to The University of Texas Southwestern Medical Center to conduct research on the role of Z-DNA in RNA polymerase III transcriptional regulation. The research aims to define the physiological functions of the Z-DNA structure, investigate the Z-DNA binding capacity of the POLR3F subunit, and...
- This Project Grant award of $440,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on two key research areas: Developing a quantitative understanding of the processes involved when contractile injection systems (e.g. phage tails, tailocins, Type VI secretion systems) breach bacterial cell envelopes. This knowledge will be applied to the design and retargeting of R-type pyocins...
- This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to determine whether pseudoenzymes, which resemble enzymes structurally but lack catalytic activity, exhibit alternative catalytic functions. The $562,800 award, effective July 1, 2025 through April 30, 2030, will allow the University of Texas Southwestern Medical Center to develop innovative strategies,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new chemical strategies for controlling the conformation of bioactive peptides and proteins. The $385,671 award, effective from September 1, 2025 to August 31, 2030, aims to synthesize and evaluate novel amino acid analogs that can influence the secondary structures of peptides and proteins, with the goal...
- This federal Project Grant award of $395,701.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to the University of Texas at Austin. The funding supports a research program to study the molecular bases of interactions between bacteria and between bacteria and their animal hosts, with a focus on insect microbiomes. The key objectives are to understand: 1) how competitive interactions between...
- This federal Project Grant award of $360,247, granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms underlying the function and regulation of signaling effectors associated with type III CRISPR-Cas systems in microbes. The research aims to advance the understanding of how these RNA-guided immune systems in bacteria and archaea use cyclic nucleotide second...
This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule (p)ppGpp, may be inactivated by metal stresses encountered during infections, promoting bacterial persistence. The research aims to reveal the drug-target potential of these alarmone hydrolases. The award period runs from September 3, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 9/3/25 |