Project Grant RM1GM156535
- The federal Project Grant award of $453,750.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to President and Fellows of Harvard College (doing business as Harvard Medical School) on April 16, 2025. The grant supports the development of advanced mass spectrometry-based proteomics workflows to improve throughput, depth, and accuracy in profiling protein abundance, post-translational...
- This federal Project Grant award for $440,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program at Northwestern University that investigates how RNA modifications, known as the epitranscriptome, regulate the translation of mRNA into proteins and how this interplay affects cell responses to stress. The research aims to fill gaps in understanding of how...
- The federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development and demonstration of a novel enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. This innovative platform leverages enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a $540,000 research project at Northwestern University to measure the global folding stability and folding energy landscapes for 3 million protein sequences. The project aims to create a large dataset quantifying these properties, which have historically been challenging to investigate at scale. This data will empower...
- This federal Project Grant award of $1,968,575.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is focused on developing computational approaches and machine learning methods to predict DNA-binding specificities for transcription factor proteins and the functional effects of genetic variants within proteins. The overarching goal is to gain a predictive understanding of proteins, their interactions,...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 Biomedical Research and Research Training provides $350,000 to Fluidispec LLC to develop a new microfluidic/nanofluidic sample preparation platform. The goal is to improve single-cell and low-input proteomics analysis by enabling efficient extraction of proteins from cells, removal of contaminants, and improved protein denaturation. This platform is expected to enhance...
- This $316,825 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The research project will develop an innovative intact mass deconvolution method to significantly improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight determination using MS. The key objectives are to implement...
- This federal Project Grant award of $427,625 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop capillaric microfluidics for integrated sample preparation in miniaturized mass spectrometry (mini-MS) systems. The research will focus on creating portable, self-powered, and self-regulated sample preparation capabilities to improve the versatility and applicability of mini-MS instruments for...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
This federal Project Grant award of $1,761,867.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northwestern University. The goal of the award is to establish the National Center for Translational and Developmental Proteomics (NCTDP), which will leverage top-down mass spectrometry methods to optimize and disseminate cutting-edge proteoform discovery and measurement technologies to the scientific community. The center will pursue a four-pronged approach, including: 1) optimizing and beta testing impactful workflows for proteoform measurement through three technology optimization projects; 2) advancing the mapping and measurement of proteoforms in 10 driving biomedical research projects; and 3) engaging academic, government, and industry proteomics communities through on-site training, beta testing, and professional development. The award was made on August 12, 2025, with an ultimate completion date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 8/11/25 |