Decoding the ubiquitin and autophagy signaling networks
Active Project Grant Awarded Last action
- Award ID
- R35GM156454
- Recipient
-
Sloan-Kettering Institute For Cancer Research UEI KUKXRCZ6NZC2
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $880,000
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 35% complete
- Place of performance
- New York, NY 10065, USA
Award details come from USAspending.gov.
Description
- Abstract
- The research program described in this proposal focuses on an in-depth exploration of the ubiquitin and autophagy pathways, which partake in a process called proteome homeostasis, or proteostasis, and is an essential cellular process. Over the course of this proposal, our team aims to uncover novel aspects of molecular intricacies of ubiquitin regulation and to explore the mechanisms underlying selective autophagy in response to various cellular stimuli. Regarding the ubiquitin machinery aspect of our work, our goal is to identify and understand the cellular relevance of recently discovered regulatory switches for ubiquitin signaling. For the autophagy facet of our work, we aim to enhance our comprehension of singular regulatory factors we'VE identified, which are involved in this complex biological process. This program combines our expertise in quantitative mass spectrometry, biochemistry, and cell biology to investigate the different aspects of proteostasis dynamics and its disruption in proteostasis-related diseases. Our investigation aims not only to advance scientific knowledge but also to have a substantial impact on healthcare by reducing our current limitations in understanding disease mechanisms.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $440,000 | |
| Original award | $440,000 |
Quick answers
Who received award R35GM156454?
R35GM156454 was awarded to Sloan-Kettering Institute For Cancer Research by National Institute of General Medical Sciences (National Institutes of Health) on February 3, 2025.
How much is award R35GM156454 worth?
$880,000 has been obligated on R35GM156454.
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