Project Grant R35GM158248
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
- This federal Project Grant award of $360,247, granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms underlying the function and regulation of signaling effectors associated with type III CRISPR-Cas systems in microbes. The research aims to advance the understanding of how these RNA-guided immune systems in bacteria and archaea use cyclic nucleotide second...
- The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially...
- This federal Project Grant award of $119,907 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to dissect the dynamics, functions, and evolution of TNPB, a miniature RNA-guided enzyme. The research aims to enhance the genome-editing efficiency of TNPB and expand its applications beyond DNA cleavage. Specifically, the project seeks to address three key knowledge gaps: (1) the molecular...
- This Project Grant award from the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS), CFDA 93.859 Biomedical Research and Research Training program, provides $385,065.00 to the University of Texas at Austin to conduct research focused on understanding the structure and function of macromolecular machines using cryo-electron microscopy (cryo-EM). The key objectives of the research are to investigate: (1) the mechanisms of RNA-guided CRISPR-Cas surveillance,...
- This federal Project Grant award of $398,774 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a strategy for efficient microinjection-free CRISPR/Cas applications in the model organism Caenorhabditis elegans (C. elegans). The project, awarded to North Carolina State University, seeks to address a key limitation in C. elegans genetic manipulation by enabling the effective delivery of...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $387,500 Project Grant to The Johns Hopkins University on May 1, 2025. The funding supports a research program that systematically investigates the roles of conserved microRNAs during animal development. The research leverages the experimental system provided by C. elegans, utilizing state-of-the-art molecular biology and genetics approaches. The...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $339,552 Project Grant to the Trustees of the Colorado School of Mines (CSM) on September 1, 2025. The grant supports CSM's research program to investigate the structure-dynamics-function relationships that regulate the biogenesis of protein complexes, with a focus on two families of bacterial proteins - S-layers and microcompartments. The goal is to...
The National Institute of General Medical Sciences (NIGMS) awarded a $501,917 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University. The grant supports research dedicated to elucidating the molecular mechanisms of RNA-guided biological systems, with a focus on CRISPR-associated transposons (CATs) and emerging RNA-guided gene regulation functions. The research aims to dissect the complex interactions and structural dynamics of these natural systems using expertise in single-particle cryo-electron microscopy and biochemical/functional assays. Key objectives include understanding the molecular basis of targeted DNA insertion by CATs, as well as exploring the structural basis of RNA-guided gene regulation to inform the development of programmable gene regulation tools. The grant has an award period from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $501.9k | 8/25/25 |